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Special Issue Title:

COVID-19 and sex differences: is the men at risk?

Deadline for manuscript submissions: 30 June 2022

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Special Issue Editor

  • Guest Editor

    Tiziana CiarambinoE-MailWebsite

    Internal Medicine Department, Hospital of Marcianise, ASL Caserta, Italy

    Interests: Gender Medicine; Aging; Chronic Kidney Disease; Emergency Medicine; Internal Medicine; Public Health

Special Issue Information

Dear Colleagues,

Study about gender distribution, suggested that males account for 60% of COVID-19 patients. Reasons are not well explored yet. Some studies showed that even MERS-CoV and SARS-CoV infected more males than females. Pre-existing diseases, such as cardiovascular or respiratory impairment, hypertension or diabetes may unfavorably impact the course of the COVID-19. However, higher risk behaviors, such as alcohol abuse and smoking, more common in male than female, may play a role in the pathophysiological process of COVID-19. However, it has been reported that hormones such as sex-specific steroids (estrogens, androgens and progesterone), and activity of X-linked genes, exert different effects on immune regulation. In fact, these modulate the innate and adaptive immune response to virus infection and influence the immune response. It is well known that estrogen suppresses T and B cell lymphopoiesis, activates B cell function and influences T cell development. Moreover, estrogen regulates a number of cytokines (such as IL-1, IL10, and IFN-beta) that modulate the immune response. Progesterone increased IL-4, reduced IFN-beta (Th17) responses and reduced T cell proliferation and T cell dependent antibody responses. However, in CD8 T cells, progesterone reduced IFN-beta and cytotoxicity. Other possible explanation about these differences between male and female subjects could be related to a higher number and activity of innate immune cells in women. In particular, females are mosaics for X-linked genes, and this contribute to generate a stronger immune response (both innate and adaptive) and more frequent autoimmune and inflammatory diseases in female subjects. However, ACE-2 represents the primary route of infection of COVID-19 and it is located on X chromosome. Actions exerted by this enzyme consist not only in the conversion of Angiotensin I, but also in immunomodulation and prevention of lung injury, with a protective effect in female subjects.

Dr. Tiziana Ciarambino

Guest Editor


Men; Sex and Gender Differences; SARS-COV2; COVID-19; Outcome

Manuscript Submission Information

Submissions will be accepted on a rolling basis and reviewed by experts in the field. Rapid peer review and prompt editorial decisions will ensure that quality manuscripts are published on time. The manuscript has not already been published or submitted elsewhere (except conference proceedings papers). If similar work has been published or submitted elsewhere, you must provide a copy of the submitted manuscript. You may not submit your manuscript elsewhere while it is under consideration at the Journal of Men's Health. All manuscripts undergo thorough double-blind peer-review. To check the suitability of the special issue for publishing your manuscript, please read the journal's aims and scope and read or download the guide for authors. You may also send a brief abstract of your work (about 100 words) to the Editorial Office at A guide for authors and other relevant information for manuscript submission is available on the Instructions for Authors page.

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Authors who feel that their manuscript may benefit from additional academic writing or language editing support before submission are strongly encouraged to use academic editing services.

Article Processing Charges (APC)

All manuscripts submitted to the Journal of Men's Health are assessed according to the journal standard editorial criteria. If accepted for publication, an Article Processing Charge of 1250 USD applies.

Type of Articles: Original Research, Review, Mini-Review, Systematic Review, Short Communication, Case Report, Letter to the Editor, Commentary, Rapid Report, Meeting Report, News and Views

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