The association between fatigue and depression in prostate cancer patients is inﬂuenced by psychological resilience
1Brain-Behaviour Research Group, University of New England, Armidale, New South Wales, Australia
2Genesiscare, John Flynn Private Hospital, Tugun, Queensland, Australia
DOI: 10.31083/jomh.v17i1.320 Vol.17,Issue 1,January 2021 pp.1-6
Published: 08 January 2021
Background and Objectives: Prostate cancer [PCa] patients often report an increase in fatigue, which can lead to elevated depression. Psychological Resilience [PR] has been shown to help people avoid depression arising from an increase in fatigue, but this has not previously been reported in PCa patients. Materials and Methods: Using an anonymous survey method, 88 PCa patients aged 44 to 88 years [M = 73.48 years, SD = 7.17 years] completed scales to measure depression, PR and fatigue. To measure changes in fatigue since before diagnosis to the time of this survey upon, participants used the "retrospective pre-test" methodology. Partial correlations were calculated for fatigue change, PR and depression to test for the effects of PR upon the association between fatigue and depression. Results: PR did not signiﬁcantly inﬂuence the association between change in fatigue and depression at the full-scale level. However, the key aspects of PR signiﬁcantly inﬂuenced the relationship for the key symptoms of depression in these men. The key aspect of PR was the patients' ability to persist; the key symptoms of depression were the ability to think clearly and to perform activities as well as they did in the past. Conclusions: Key aspects of PR may reduce the depressive effects of fatigue in PCa patients, suggesting possible treatment foci for assisting these men deal with this negative side effect from their diagnosis and treatment.
Cancer; Prostate; Depression; Fatigue; Resilience
Christopher F. Sharpley,David R. H. Christie,Vicki Bitsika. The association between fatigue and depression in prostate cancer patients is inﬂuenced by psychological resilience. Journal of Men's Health. 2021. 17(1);1-6.
 Watts S, Leydon G, Birch B, Prescott P, Lai L, Eardley S, et al. Depression and anxiety in prostate cancer: a systematic review and meta-analysis of prevalence rates. BMJ Open. 2014; 4: e003901.
 Korfage IJ, Essink-Bot ML, Janssens AC, Schröder FH, de Koning HJ. Anxiety and depression after prostate cancer diagnosis and treatment: 5-year follow-up. British Journal of Cancer. 2006; 94: 1093-1098.
 Langston B, Armes J, Levy A, Tidey E, Ream E. The prevalence and severity of fatigue in men with prostate cancer: A systematic review of the literature. Support Care Cancer. 2013; 21: 1761-1771.
 Brown L, Kroenke K. Cancer-related fatigue and its associations with depression and anxiety: a systematic review. Psychosomatics. 2009; 50: 440-447.
 Jones JM, Olson K, Catton P, Catton CN, Fleshner NE, Krzyzanowska MK, et al. Cancer-related fatigue and associated disability in post-treatment cancer survivors. Journal of Cancer Survivorship. 2016; 10: 51-61.
 Sharpley CF, Bitsika V, Wootten AC, Christie DR. Does resilience “buffer” against depression in prostate cancer patients? A multi-site replication. European Journal of Cancer Care. 2014; 23: 545-552.
 Luthar S, Cicchetti D. The construct of resilience: Implications for interventions and social policies. Development and Psychopathology. 2000; 12: 857-885.
 Feder A, Nestler EJ, Charney DS. Psychobiology and molecular genetics of resilience. Nature Reviews Neuroscience. 2009; 10: 446-457.
 Mccraty R, Atkinson M. Resilience training program reduces physiological and psychological stress in police officers. Global Advances in Health and Medicine. 2012; 1: 44-66.
 Rutter M. Resilience as a dynamic concept. Development and Psy-chopathology. 2012; 24: 335-344.
 Sharpley C, Bitsika V, Christie D. “Steeling” effects in the association between psychological resilience and cancer treatment in prostate cancer patients. Psycho-Oncology. 2020. (in press)
 APA. Diagnostic and statistical manual of mental disorders. 5th ed. Washington, DC: American Psychiatric Association. 2013.
 Insel T. Transforming diagnosis. 2013. Available at: www.nimh.nih. gov/about/director/2013/transforming-diagnosis-shtml (cited: 2013 May 27).
 Krupp LB, LaRocca NG, Muir-Nash J, Steinberg AD. The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. Archives of Neurology. 1989; 46: 1121-1123.
 Stone P, Richards M, A’Hern R, Hardy J. A study to investigate the prevalence, severity and correlates of fatigue among patients with cancer in comparison with a control group of volunteers without cancer. Annals of Oncology. 2000; 11: 561-567.
 Stone P, Hardy J, Huddart R, A’Hern R, Richards M. Fatigue in patients with prostate cancer receiving hormone therapy. European Journal of Cancer. 2000; 36: 1134-1141.
 Connor K, Davidson J. Development of a new resilience scale: the Connor-Davidson Resilience Scale (CD-RISC). Depress Anxiety. 2003; 18: 76-82.
 Zung W. A self-rating depression scale. Archives of General Psychiatry. 1965; 12: 63-70.
 Zung W. From art to science: The diagnosis and treatment of depression. Archives of General Psychiatry. 1973; 29: 328-337.
 DeJonge J, Baneke J. The Zung self-rating depression scale: a replication study on reliability, validity and prediction. Psychological Reports. 1989; 64: 833-834.
 Gabrys J, Peters K. Reliability, discriminant and predictive validity of the Zung self-rating depression scale. Psychological Reports. 1985; 57: 1091-1096.
 Sharpley C, Bitsika V, Christie D. Understanding the causes of depression among prostate cancer patients: Development of the effects of prostate cancer on lifestyle questionnaire. Psycho-Oncology. 2009; 18: 162-168.
 Schaefer A, Brown J, Watson CG, Plemel D, DeMotts J, Howard MT, et al. Comparison of the validities of the Beck, Zung and MMPI depression scales. Journal of Consulting and Clinical Psychology. 1985; 53: 415-418.
 Howard GS, Ralph KM, Gulanik NA, Maxwelle SE, Nance DW, Gerber SK. Internal validity in pre-test -post-test self-report evaluations and a re-evaluation of retrospective pre-tests. Applied Psychological Measurement. 1979; 3: 1-23.
 Campbell D, Stanley J. Experimental and quasi-experimental designs for research. Chicago, IL: Rand McNally. 1963.
 Sharpley C, Christie D. “How I was then and how I am now”: Current and retrospective self-reports of anxiety and depression in Australian women with breast cancer. Psycho-Oncology. 2007; 16: 752-762.
 Tabachnik B, Fidell L. Using multivariate statistics. 6th ed. Boston, MA: Pearson Education. 2013.
 O’Higgins CM, Brady B, O’Connor B, Walsh D, Reilly RB. The patho-physiology of cancer-related fatigue: current controversies. Support Care Cancer. 2018; 26: 3353-3364.
 Charalambous AGM, Bozas E, Paikousis L. Parallel and serial mediation analysis between pain, anxiety, depression, fatigue and nausea, vomiting and retching within a randomised controlled trial in patients with breast and prostate cancer. BMJ Open. 2019; 9: e026809.
 Monga U, Kerrigan AJ, Thornby J, Monga TN. Prospective study of fatigue in localized prostate cancer patients undergoing radiotherapy. Radiation Oncology Investigations. 1999; 7: 178-185.
 Chao HH, Doucette A, Raizen DM, Vapiwala N. Factors associated with fatigue in prostate cancer (PC) patients undergoing external beam radiation therapy (EBRT). Practical Radiation Oncology. 2018; 8: e139-148.
 Loprinzi CE, Prasad K, Schroeder DR, Sood A. Stress management and resilience training (SMART) program to decrease stress and enhance resilience among breast cancer survivors: a pilot randomized clinical trial. Clinical Breast Cancer. 2011; 11: 364-368.
 Reivich K, Seligman M, McBride S. Master resilience training in the U.S. Army. American Psychologist. 2011; 66: 25-34.
 Arnetz B, Nevedal D, Lumley M, Backman L, Lublin A. Trauma resilience training for police: psychophysiological and performance effects. Journal of Police and Criminal Psychology. 2009; 24: 1-9.
 Robertson I, Cooper C, Sarkar M, Curran T. Resilience training in the workplace from 2003 to 2014: a systematic review. Journal of Occupational and Organizational Psychology. 2015; 88: 533-562.
 Sood A, Prasad K, Schroeder D, Varkey P. Stress management and resilience training among department of medicine faculty: A pilot randomized clinical trial. Journal of General Internal Medicine. 2011; 26: 858-861.
 Carlsson S, Sandin F, Fall K, Lambe M, Adolfsson J, Stattin P, et al. Risk of suicide in men with low-risk prostate cancer. European Journal of Cancer. 2013; 49: 1588-1599.
 Jayadevappa R, Malkowicz SB, Chhatre S, Johnson JC, Gallo JJ. The burden of depression in prostate cancer. Psycho-Oncology 2012; 21: 1338-1345.
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