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Original Research

Open Access Special Issue

PTX3 as a biomarker of lowered arterial stiffness due to weight loss in overweight and obese Japanese men

  • Asako Zempo-Miyaki1
  • Hiroshi Kumagai2
  • Toru Yoshikawa1
  • Kiyoji Tanaka3
  • Seiji Maeda3,4

1Faculty of Sports & Health Science, Ryutsu Keizai University, 301-8555 Ibaraki, Japan

2The Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA

3Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, 305-8574 Ibaraki, Japan

4Faculty of Sport Sciences, Waseda University, Tokorozawa, 359-1192 Saitama, Japan

DOI: 10.31083/jomh.2021.139

Submitted: 23 August 2021 Accepted: 17 September 2021

Online publish date: 27 October 2021

*Corresponding Author(s): Asako Zempo-Miyaki E-mail: zempo@rku.ac.jp

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Abstract

Background: Obesity, an independent cardiovascular disease risk factor, is the leading cause of death in the world. It has been previously shown that arterial stiffness,which is an index of cardiovascular disease, is significantly higher in Japanese overweight and obese men. Increased levels of pentraxin3 (PTX3), a novel anti-inflammatory substance mainly produced in the atherosclerotic region, due to weight reduction has been proposed to reflect an improvement in arterial stiffness. However, this has not been investigated.

Methods: Here, we elucidate whether an individual who has significantly increased plasma PTX3 concentration result in a significantly decreased arterial stiffness compared to a smaller change in PTX3 level after a 12-week dietary modified weight reduction program in twenty overweight or obese Japanese men. A well-balanced dietary modification weight-loss program was implemented for overweight and obese men over a course of 12-week.

Results: Prior to and after the program, we measured anthropometric variables, blood pressure, arterial stiffness, and circulating biochemistry, including plasma PTX3 concentrations. We then compared the differences in arterial stiffness between two groups, low or high ∆PTX3 groups, based on the median of delta of plasma PTX3 levels before and after weight reduction via modified diet habit in men with overweight and obesity. Carotid-femoral pulse wave velocity (PWV) as index of central arterial stiifness and brachial-ankle PWV as index of whole body arterial stiffness were significantly decreased in the high ∆PTX3 group after dietary modification.

Conclusions: Our present results suggest that PTX3 could be a clinically useful biochemical index for monitoring appropriate arterial function maintenance in obese weight control.

Keywords

Inflammation; Obesity; PTX3; Weight loss; Men

Cite and Share

Asako Zempo-Miyaki,Hiroshi Kumagai,Toru Yoshikawa,Kiyoji Tanaka,Seiji Maeda. PTX3 as a biomarker of lowered arterial stiffness due to weight loss in overweight and obese Japanese men. Journal of Men's Health. 2021.doi:10.31083/jomh.2021.139.

References

[1] Hubert HB, Feinleib M, McNamara PM, Castelli WP. Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study. Circulation. 1983; 67: 968–977.

[2] Miyaki A, Maeda S, Choi Y, Akazawa N, Eto M, Tanaka K, et al. As-sociation of Plasma Pentraxin 3 with Arterial Stiffness in Overweight and Obese Individuals. American Journal of Hypertension. 2013; 26: 1250–1255.

[3] Wildman RP, Mackey RH, Bostom A, Thompson T, Sutton-Tyrrell K. Measures of Obesity are Associated with Vascular Stiffness in Young and Older Adults. Hypertension. 2003; 42: 468–473.

[4] Miyaki A, Maeda S, Yoshizawa M, Misono M, Saito Y, Sasai H, et al. Effect of weight reduction with dietary intervention on arterial distensibility and endothelial function in obese men. Angiology. 2009; 60: 351–357.

[5] Miyaki A, Maeda S, Yoshizawa M, Misono M, Saito Y, Sasai H, et al. Effect of Habitual Aerobic Exercise on Body Weight and Arterial Function in Overweight and Obese Men. American Journal of Cardiology. 2009; 104: 823–828.

[6] Zempo-Miyaki A, Kumagai H, Yoshikawa T, Myoenzono K, So R, Otsuki T, et al. Pentraxin 3 increases in adult overweight and obese men after weight loss by dietary modification with exercise training. Applied Physiology, Nutrition, and Metabolism. 2019; 44: 111–117.

[7] Hiraoka H, Hanaoka Y, Jesmin S, Kimura F, Matsuish Y, Shimizu K, et al. Variation of Salivary IgA during Weight Loss Period before a Competition among University Judo Players. Journal of Clinical Medicine Research. 2019; 11: 798–806.

[8] Tartof SY, Qian L, Hong V, Wei R, Nadjafi RF, Fischer H, et al. Obesity and Mortality among Patients Diagnosed with COVID-19: Results from an Integrated Health Care Organization. Annals of Internal Medicine. 2020; 173: 773–781.

[9] Lau DC, Dhillon B, Yan H, Szmitko PE, Verma S, et al. Adipokines: molecular links between obesity and atherosclerosis. American Journal of Physiology-Heart and Circulatory Physiology. 2005; 288: H2031–H2041.

[10] Ristagno G, Fumagalli F, Bottazzi B, Mantovani A, Olivari D, Novelli1 D, et al. Pentraxin 3 in cardiovascular disease. Front in Immunology. 2019; 10: 823.

[11] Okura T, Nakata Y, Yamabuki K, Tanaka K. Regional body compo-sition changes exhibit opposing effects on coronary heart disease risk factors. Arteriosclerosis, Thrombosis, and Vascular Biology. 2004; 24: 923–929.

[12] Yasunaga T, Ikeda S, Koga S, Nakata T, Yoshida T, Masuda N, et al. Plasma pentraxin 3 is a more potent predictor of endothelial dysfunction than high-sensitive C-reactive protein. International Heart Journal. 2014; 55: 160–164.

[13] Suliman ME, Yilmaz MI, Carrero JJ, Qureshi AR, Saglam M, Ipcioglu OM, et al. Novel links between the long pentraxin 3, endothelial dysfunction, and albuminuria in early and advanced chronic kidney disease. Clinical Journal of the American Society of Nephrology. 2008; 3: 976–985.

[14] Kocyigit I, Eroglu E, Orscelik O, Unal A, Gungor O, Ozturk F, et al. Pentraxin 3 as a novel bio-marker of inflammation and endothelial dysfunction in autosomal dominant polycystic kidney disease. Journal of Nephrology. 2014; 27: 181–186.

[15] Norata GD, Marchesi P, Pulakazhi Venu VK, Pasqualini F, Anselmo A, Moalli F, et al. Deficiency of the Long Pentraxin PTX3 Promotes Vascular Inflammation and Atherosclerosis. Circulation. 2009; 120: 699–708.

[16] Salio M, Chimenti S, De Angelis N, Molla F, Maina V, Nebuloni M, et al. Cardioprotective function of the long pentraxin PTX3 in acute myocardial infarction. Circulation. 2008; 117: 1055–1064.

[17] Miyaki A, Maeda S, Choi Y, Akazawa N, Tanabe Y, So R, et al. The addition of whole-body vibration to a lifestyle modification on arterial stiffness in overweight and obese women. Artery Research. 2012; 6: 85–91.

[18] Miyaki A, Maeda S, Otsuki T, Ajisaka R. Plasma pentraxin 3 concentration increases in endurance-trained men. Medicine and Science in Sports and Exercise. 2011; 43: 12–17.

[19] Maeda S, Zempo-Miyaki A, Sasai H, Tsujimoto T, So R, Tanaka K. Lifestyle Modification Decreases Arterial Stiffness in Overweight and Obese Men: Dietary Modification vs. Exercise Training. International Journal of Sport Nutrition and Exercise Metabolism. 2015; 25: 69–77.

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