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Original Research

Open Access Special Issue

Is serum vitamin D level a risk factor for idiopathic male fertility?

  • Mustafa Ozan Horsanalı1
  • Huseyin Eren2
  • Alper Caglayan3
  • Yasar Issi4

1Urology Department, Faculty of Medicine, Izmir Bakırçay University, 35665 Izmir, Turkey

2Urology Department, Faculty of Medicine, Recep Tayyip Erdogan University, 53100 Rize, Turkey

3Urology Department, Izmir Bakırçay University Cigli Training and Research Hospital, 35620 Izmir, Turkey

4Urology Department, Faculty of Medicine, Izmir Bakırçay University, 35665 Izmir, Turkey

DOI: 10.31083/jomh.2021.138

Submitted: 03 August 2021 Accepted: 18 September 2021

Online publish date: 27 October 2021

*Corresponding Author(s): Mustafa Ozan Horsanalı E-mail: ozan.horsanali@bakircay.edu.tr

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Abstract

Background: Idiopathic male infertility is a health problem that is increasingly common worldwide. Aetiology of idiopathic male infertility is still controversial. In this cross-sectional retrospective study, we aimed to investigate the relationship between serum vitamin D level and sperm quality in patients with idiopathic male infertility.

Methods: Between June 2018 and June 2020, 297 patients including 147 men with idiopathic infertility (as a study group) and 150 fertile men (as a control group) were retrospectively enrolled into the study. Blood samples were collected, and these samples included serum sex steroids, serum vitamin D levels, glucose tests, lipid profiles, liver function tests and kidney function tests. At least two sperm analyses, scrotal doppler ultrasonography and karyotype analysis were performed on each of the patients. Demographic, laboratory and radiological features were also recorded. The Mann Whitney-U test was used to compare groups and quantitative independent data. The Chi-square test was used for qualitative independent data. Spearman's correlation analysis was applied for correlation. Significant results were investigated and analysed further using the logistic regression test.

Results: The mean age of the patients was 31.98 ± 6.97 years. The mean serum vitamin D level of the patients was 23.16 ± 10.40 ng/dL and the mean infertility duration of patients with idiopathic infertility was 29.88 ± 28.86 months. We observed statistical significance in terms of serum vitamin D levels, impaired total sperm motility, progressive sperm motility and sperm morphology in idiopathic infertile men when compared to fertile men. There were no statistically significant between idiopathic infertile men and fertile men in terms of serum testosterone levels.

Conclusions: We observed a positive correlation between serum vitamin D levels and impaired sperm parameters, specifically in terms of sperm morphology, total sperm motility and progressive sperm motility. Vitamin D supplementation may be a beneficial contribution to achieving high paternity rates in men with idiopathic male infertility.

Keywords

Infertility; Vitamin D; Testosterone; Semen; Spermiogram

Cite and Share

Mustafa Ozan Horsanalı,Huseyin Eren,Alper Caglayan,Yasar Issi. Is serum vitamin D level a risk factor for idiopathic male fertility?. Journal of Men's Health. 2021.doi:10.31083/jomh.2021.138.

References

[1] Fainberg J, Kashanian JA. Recent advances in understanding and managing male infertility. F1000Research. 2019; 8: F1000 Faculty Rev-670.

[2] Greenhall E, Vessey M. The prevalence of subfertility: a review of the current confusion and a report of two new studies. Fertility and Sterility. 1990; 54: 978–983.

[3] Agarwal A, Parekh N, Panner Selvam MK, Henkel R, Shah R, Homa ST, et al. Male Oxidative Stress Infertility (MOSI): Proposed Terminology and Clinical Practice Guidelines for Management of Idiopathic Male Infertility. The World Journal of Men’s Health. 2019; 37: 296–312.

[4] Fichera M, Török P, Tesarik J, Della Corte L, Rizzo G, Garzon S, et al. Vitamin D, reproductive disorders and assisted reproduction: evidences and perspectives. International Journal of Food Sciences and Nutrition. 2020; 71: 276–285.

[5] Norman AW. The history of the discovery of vitamin D and its daughter steroid hormone. Annals of Nutrition & Metabolism. 2012; 61: 199–206.

[6] Pawlowska E, Wysokinski D, Blasiak J. Nucleotide Excision Repair and Vitamin D—Relevance for Skin Cancer Therapy. International Journal of Molecular Sciences. 2016; 17: 372.

[7] Blomberg Jensen M, Jørgensen A, Nielsen JE, Bjerrum PJ, Skalkam M, Petersen JH, et al. Expression of the vitamin D metabolizing enzyme CYP24a1 at the annulus of human spermatozoa may serve as a novel marker of semen quality. International Journal of Andrology. 2012; 35: 499–510.

[8] Kwiecinski GG, Petrie GI, DeLuca HF. Vitamin D is necessary for reproductive functions of the male rat. The Journal of Nutrition. 1989; 119: 741–744.

[9] Uhland AM, Kwiecinski GG, DeLuca HF. Normalization of serum calcium restores fertility in vitamin D-deficient male rats. The Journal of Nutrition. 1992; 122: 1338–1344.

[10] Kinuta K, Tanaka H, Moriwake T, Aya K, Kato S, Seino Y. Vitamin D is an important factor in estrogen biosynthesis of both female and male gonads. Endocrinology. 2000; 141: 1317–1324.

[11] Parikh G, Varadinova M, Suwandhi P, Araki T, Rosenwaks Z, Poretsky L, et al. Vitamin D regulates steroidogenesis and insulin-like growth factor binding protein-1 (IGFBP-1) production in human ovarian cells. Hormone and Metabolic Research. 2010; 42: 754–757.

[12] Jorde R, Grimnes G, Hutchinson MS, Kjærgaard M, Kamycheva E, Svartberg J. Supplementation with vitamin D does not increase serum testosterone levels in healthy males. Hormone and Metabolic Research. 2013; 45: 675–681.

[13] O’Donnell L, Stanton P, de Kretser DM. Endocrinology of the Male Reproductive System and Spermatogenesis. MDText.com, Inc.: South Dartmouth. 2015.

[14] O’Shaughnessy PJ, Monteiro A, Verhoeven G, De Gendt K, Abel MH. Effect of FSH on testicular morphology and spermatogenesis in gonadotrophin-deficient hypogonadal mice lacking androgen recep-tors. REPRODUCTION. 2010; 139: 177–184.

[15] Khera M. Male hormones and men’s quality of life. Current Opinion in Urology. 2016; 26: 152–157.

[16] Ramaswamy S, Weinbauer GF. Endocrine control of spermatogenesis: Role of FSH and LH/testosterone. Spermatogenesis. 2014; 4: e996025.

[17] Bellastella G, Maiorino MI, Olita L, Capuano A, Rafaniello C, Giugliano D, et al. Vitamin D deficiency in type 2 diabetic patients with hypogonadism. The Journal of Sexual Medicine. 2014; 11: 536–542.

[18] Wehr E, Pilz S, Boehm BO, März W, Obermayer-Pietsch B. Associa-tion of vitamin D status with serum androgen levels in men. Clinical Endocrinology. 2010; 73: 243–248.

[19] Chin K, Ima-Nirwana S, Wan Ngah WZ. Vitamin D is significantly associated with total testosterone and sex hormone-binding globulin in Malaysian men. The Aging Male. 2015; 18: 175–179.

[20] Wulaningsih W, Van Hemelrijck M, Michaelsson K, Kanarek N, Nelson WG, Ix JH, et al. Association of serum inorganic phosphate with sex steroid hormones and vitamin D in a nationally representative sample of men. Andrology. 2014; 2: 967–976.

[21] Ceglia L, Chiu GR, Harris SS, Araujo AB. Serum 25-hydroxyvitamin D concentration and physical function in adult men. Clinical Endocrinol-ogy. 2011; 74: 370–376.

[22] Blomberg Jensen M, Nielsen JE, Jørgensen A, Rajpert-De Meyts E, Kristensen DM, Jørgensen N, et al. Vitamin D receptor and vitamin D metabolizing enzymes are expressed in the human male reproductive tract. Human Reproduction. 2010; 25: 1303–1311.

[23] Johnson JA, Grande JP, Roche PC, Kumar R. Immunohistochemical detection and distribution of the 1,25-dihydroxyvitamin D3 receptor in rat reproductive tissues. Histochemistry and Cell Biology. 1996; 105: 7–15.

[24] Oury F, Ferron M, Huizhen W, Confavreux C, Xu L, Lacombe J, et al. Osteocalcin regulates murine and human fertility through a pancreas-bone-testis axis. The Journal of Clinical Investigation. 2013; 123: 2421–2433.

[25] Aquila S, Guido C, Middea E, Perrotta I, Bruno R, Pellegrino M, et al. Human male gamete endocrinology: 1alpha, 25-dihydroxyvitamin D3 (1,25(OH)2D3) regulates different aspects of human sperm biology and metabolism. Reproductive Biology and Endocrinology. 2009; 7: 140.

[26] Blomberg Jensen M, Bjerrum PJ, Jessen TE, Nielsen JE, Joensen UN, Olesen IA, et al. Vitamin D is positively associated with sperm motility and increases intracellular calcium in human spermatozoa. Human Reproduction. 2011; 26: 1307–1317.

[27] Yang B, Sun H, Wan Y, Wang H, Qin W, Yang L, et al. Associations between testosterone, bone mineral density, vitamin D and semen quality in fertile and infertile Chinese men. International Journal of Andrology. 2012; 35: 783–792.

[28] Tirabassi G, Cutini M, Muscogiuri G, delli Muti N, Corona G, Galdiero M, et al. Association between vitamin D and sperm parameters: Clinical evidence. Endocrine. 2017; 58: 194–198.

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