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Original Research

Open Access

Global research trends on the absence of vas deferens: a bibliometric and visualized study

  • Chengquan Ma1
  • Jiahui Xing1
  • Hongjun Li1

1Department of Urology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, 100730 Beijing, China

DOI: 10.31083/jomh.2021.130

Submitted: 22 July 2021 Accepted: 09 September 2021

Online publish date: 13 October 2021

*Corresponding Author(s): Hongjun Li E-mail:

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Background and objectives: To conduct a bibliometric analysis of publications on the absence of vas deferens (AVD) and explore hot topics regarding the subject.

Material and methods: Publications about AVD research were retrieved from the Web of Science Core Collection (WoSCC). We conducted bibliometric analyses using CiteSpace and VOSviewer software. The results parameters were authors, number of publications, top institutions/countries, impact factor and citation analysis. In addition, network maps were presented to evaluate the collaborations between them.

Results: A total of 918 articles were included in the analysis. Since 1998, the number of publications has gradually declined. Human reproduction (69) represented the most papers and was also the most co-cited journal. Silber Sj, Asch Rh and Patrizio P were leading researchers, and there were active collaborations among the top authors. The USA was the leading national contributor in this field, with 231 publications, and active cooperation between countries and institutions was observed. Hot topics included the themes of congenital bilateral absence, cystic fibrosis, infertility and mutations.

Conclusion: Research papers on AVD gradually decreased after 1998. This historical overview of research on AVD will be useful for further research. Future research on specific areas regarding hot topics is recommended.


Absence of the vas deferens (AVD); Bibliometric analysis; Cystic fibrosis transmembrane conductance regulator (CFTR); Cystic fibrosis

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Chengquan Ma,Jiahui Xing,Hongjun Li. Global research trends on the absence of vas deferens: a bibliometric and visualized study. Journal of Men's Health. 2021.doi:10.31083/jomh.2021.130.


[1] Hussein TM, Zakaria NH, Zahran AM. Clinical, laboratory and genetic assessment of patients with congenital bilateral absent vas deferens. Andrologia. 2011; 43: 16–22.

[2] Zhang M, Gao M, Yue S, Zheng T, Gao Z, Ma X, et al. Global trends and future prospects of food waste research: a bibliometric analysis. Environmental Science and Pollution Research. 2018; 25: 24600–24610.

[3] Chen C. CiteSpace II: Detecting and visualizing emerging trends and transient patterns in scientific literature. Journal of the American Society for Information Science and Technology. 2006; 57: 359–377.

[4] Bornmann L, Leydesdorff L. Scientometrics in a changing research landscape: bibliometrics has become an integral part of research quality evaluation and has been changing the practice of research. EMBO Reports. 2014; 15: 1228–1232.

[5] Miao Y, Zhang Y, Yin L. Trends in hepatocellular carcinoma research from 2008 to 2017: a bibliometric analysis. PeerJ. 2018; 6: e5477.

[6] Baek S, Yoon DY, Lim KJ, Cho YK, Seo YL, Yun EJ. The most down-loaded and most cited articles in radiology journals: a comparative bibliometric analysis. European Radiology. 2018; 28: 4832–4838.

[7] Hui J, He S, Liu R, Zeng Q, Zhang H, Wei A. Trends in erectile dysfunction research from 2008 to 2018: a bibliometric analysis. International Journal of Impotence Research. 2020; 32: 409–419.

[8] Plyler ZE, Birket SE, Schultz BD, Hong JS, Rowe SM, Petty CF, et al. Non-obstructive vas deferens and epididymis loss in cystic fibrosis rats. Mechanisms of Development. 2019; 155: 15–26.

[9] Houzet L, Pérez-Losada M, Matusali G, Deleage C, Dereuddre-Bosquet N, Satie A, et al. Seminal Simian Immunodeficiency Virus in Chronically Infected Cynomolgus Macaques is Dominated by Virus Originating from Multiple Genital Organs. Journal of Virology. 2018; 92: e00133-18.

[10] Pietrement C, Da Silva N, Silberstein C, James M, Marsolais M, Van Hoek A, et al. Role of NHERF1, cystic fibrosis transmembrane conductance regulator, and cAMP in the regulation of aquaporin 9. The Journal of Biological Chemistry. 2008; 283: 2986–2996.

[11] Yang B, Wang X, Zhang W, Li H, Wang B. Compound heterozygous mutations in CFTR causing CBAVD in Chinese pedigrees. Molecular Genetics & Genomic Medicine. 2018; 6: 1097–1103.

[12] Tomaszewski J, Joseph A, Archambeault D, Yao HH. Essential roles of inhibin beta a in mouse epididymal coiling. Proceedings of the National Academy of Sciences of the United States of America. 2007; 104: 11322–11327.

[13] Silber S, Ord T, Borrero C, Balmaceda J, Asch R. New treatment for infertility due to congenital absence of vas deferens. Lancet. 1987; 2: 850–851.

[14] Dou Y, Huang Q, He C, Meng S, Zhang Q. Rapid Population Growth throughout Asia’s Earthquake-Prone Areas: a Multiscale Analysis. International Journal of Environmental Research and Public Health. 2018; 15: 1893.

[15] Xiong K, Wang L, Chen X, Cao Y, Xiang C, Xue L, et al. Analysis of projects received and funded in fields of emergency and intensive care medicine/trauma/burns/plastic surgery from National Natural Science Foundation of China during 2010-2013. Zhonghua wei zhong bing ji jiu yi xue. 2014; 26: 11–16. (In Chinese)

[16] Wan Q, Xu Y, Dong E. Diabetic nephropathy research in China: Data analysis and review from the National Natural Science Foundation of China. Journal of Diabetes. 2015; 7: 307–314.

[17] Patrizio P, Ord T, Silber SJ, Asch RH. Correlation between epididymal length and fertilization rate in men with congenital absence of the vas deferens. Fertility and Sterility. 1994; 61: 265–268.

[18] Liu J, Lissens W, Silber SJ, Devroey P, Liebaers I, Van Steirteghem A. Birth after preimplantation diagnosis of the cystic fibrosis delta F508 mutation by polymerase chain reaction in human embryos resulting from intracytoplasmic sperm injection with epididymal sperm. Journal of the American Medical Association. 1994; 272: 1858–1860.

[19] Bieth E, Hamdi SM, Mieusset R. Genetics of the congenital absence of the vas deferens. Human Genetics. 2021; 140: 59–76.

[20] Ma C, Wang R, Li T, Li H, Wang B. Analysis of CNVs of CFTR gene in Chinese Han population with CBAVD. Molecular Genetics & Genomic Medicine. 2020; 8: e1506.

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