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Original Research

Open Access

Fertility outcome of patients with CBAVD: a single-institution experience

  • Chengquan Ma1
  • Zhengyi Sun2
  • Jing Wang3
  • Binbin Wang4
  • Hongjun Li1

1Department of Urology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, 100730 Beijing, China

2Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, 100730 Beijing, China

3Department of Medical Genetics and Developmental Biology, School of Basic Medical Sciences, Capital Medical University, 100069 Beijing, China

4Center for Genetics, National Research Institute for Family Planning, 100081 Beijing, China

DOI: 10.31083/jomh.2021.120

Submitted: 28 July 2021 Accepted: 09 September 2021

Online publish date: 16 September 2021

*Corresponding Author(s): Binbin Wang E-mail:
*Corresponding Author(s): Hongjun Li E-mail:

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Background and objective: Congenital bilateral absence of the vas deferens (CBAVD) is not common and fertility outcome is not clear. This study is to report fertility outcomes of infertile male with CBAVD.

Material and methods: Our study cohort comprised CBAVD males who were enrolled from 2005 to 2019. Baseline information was collected including mean age, previous medical history, duration of infertility, sex hormone assays, ejaculate volume/pH, parameters of sperm retrieved by percutaneous epididymal sperm aspiration (PESA), development of seminal vesicle TRUS, follow up fertility outcomes of the patients with Intracytoplasmic sperm injection (ICSI)and compared the impact of varies male factors on fertility outcomes.

Results: 172 participants with CBAVD were analyzed. A total of 211 ICSI cycles were performed and the live birth rate was 46.92%. Among 126 live births, 57 (45.24%) were boy and 69 (54.76%) were girl. The neonatal weight and height are 3036.83 ± 672.17 g, 49.43 ± 2.49 cm, respectively. There were no significant differences between successes group of couples and fail group of couples for first ICSI cycles cases in terms of age (P = 0.09), testicle volume (left P = 0.96, right P = 0.41), sex hormones (P > 0.05), ejaculate volume (P = 0.79), ejaculate pH (P = 0.78) or sperm quality parameters from PESA (P > 0.05). Conclusions: This study indicates that the clinical characteristics of male with CBAVD had no impact on fertility outcomes.


Male infertility; CBAVD; Fertility outcome; Percutaneous epididymal sperm aspiration; Intracytoplasmic sperm injection

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Chengquan Ma,Zhengyi Sun,Jing Wang,Binbin Wang,Hongjun Li. Fertility outcome of patients with CBAVD: a single-institution experience. Journal of Men's Health. 2021.doi:10.31083/jomh.2021.120.


[1] Jequier AM, Ansell ID, Bullimore NJ. Congenital absence of the vasa deferentia presenting with infertility. Journal of Andrology. 1985; 6: 15–19.

[2] Hussein TM, Zakaria NH, Zahran AM. Clinical, laboratory and genetic assessment of patients with congenital bilateral absent vas deferens. Andrologia. 2011; 43: 16–22.

[3] Dumur V, Gervais R, Rigot JM, Delomel-Vinner E, Decaestecker B, Lafitte JJ, et al. Congenital bilateral absence of the vas deferens (CBAVD) and cystic fibrosis transmembrane regulator (CFTR): correlation between genotype and phenotype. Human Genetics. 1996; 97: 7–10.

[4] Fedder J, Jørgensen MW, Engvad B. Prevalence of CBAVD in azoospermic men carrying pathogenic CFTR mutations - Evaluated in a cohort of 639 non-vasectomized azoospermic men. Andrology. 2021; 9: 588–598.

[5] Lotti F, Maggi M. Ultrasound of the male genital tract in relation to male reproductive health. Human Reproduction Update. 2015; 21: 56–83.

[6] Dohle GR, Veeze HJ, Overbeek SE, van den Ouweland AMW, Halley DJJ, Weber RFA, et al. The complex relationships between cystic fibrosis and congenital bilateral absence of the vas deferens: clinical, electrophysiological and genetic data. Human Reproduction. 1999; 14: 371–374.

[7] Silber SJ, Nagy ZP, Liu J, Godoy H, Devroey P, Van Steirteghem AC. Conventional in-vitro fertilization versus intracytoplasmic sperm in-jection for patients requiring microsurgical sperm aspiration. Human Reproduction. 1994; 9: 1705–1709.

[8] Craft I, Bennett V, Nicholson N. Fertilising ability of testicular spermatozoa. Lancet. 1993; 342: 864.

[9] Ządzińska E, Rosset I, Mikulec A, Domański C, Pawłowski B. Impact of economic conditions on the secondary sex ratio in a post-communist economy. Homo. 2011; 62: 218–227.

[10] Hamamatsu Y, Inoue Y, Watanabe C, Umezaki M. Impact of the 2011 earthquake on marriages, births and the secondary sex ratio in Japan. Journal of Biosocial Science. 2014; 46: 830–841.

[11] Fareed M, Kaisar Ahmad M, Azeem Anwar M, Afzal M. Impact of consanguineous marriages and degrees of inbreeding on fertility, child mortality, secondary sex ratio, selection intensity, and genetic load: a cross-sectional study from Northern India. Pediatric Research. 2017; 81: 18–26.

[12] Bae J, Kim S, Barr DB, Buck Louis GM. Maternal and paternal serum concentrations of persistent organic pollutants and the secondary sex ratio: a population-based preconception cohort study. Environmental Research. 2018; 161: 9–16.

[13] Yorifuji T, Kashima S. Secondary sex ratio in regions severely exposed to methylmercury “Minamata disease”. International Archives of Occupational and Environmental Health. 2016; 89: 659–665.

[14] Matsuo K, Ushioda N, Udoff LC. Parental aging synergistically decreases offspring sex ratio. Journal of Obstetrics and Gynaecology Research. 2009; 35: 164–168.

[15] Bae J, Kim S, Chen Z, Eisenberg ML, Buck Louis GM. Human semen quality and the secondary sex ratio. Asian Journal of Andrology. 2017; 19: 374–381.

[16] Hubert D, Patrat C, Guibert J, Thiounn N, Bienvenu T, Viot G, et al. Results of assisted reproductive technique in men with cystic fibrosis. Human Reproduction. 2006; 21: 1232–1236.

[17] Ge B, Zhang M, Wang R, Wang D, Li T, Li H, et al. A rare frameshift variant in trans with the IVS9-5T allele of CFTR in a Chinese pedigree with congenital aplasia of vas deferens. Journal of Assisted Reproduction and Genetics. 2019; 36: 2541–2545.

[18] Li Z, Wang AY, Bowman M, Hammarberg K, Farquhar C, Johnson L, et al. ICSI does not increase the cumulative live birth rate in non-male factor infertility. Human Reproduction. 2018; 33: 1322–1330.

[19] Esteves SC. Percutaneous epididymal sperm aspiration as a method for sperm retrieval in men with obstructive azoospermia seeking fertility: operative and laboratory aspects. International Brazilian Journal of Urology. 2015; 41: 817–818.

[20] Moffat R, Beutler S, Schötzau A, De Geyter M, De Geyter C. Endometrial thickness influences neonatal birth weight in pregnancies with obstetric complications achieved after fresh IVF-ICSI cycles. Archives of Gynecology and Obstetrics. 2017; 296: 115–122.

[21] Fedder J, Gabrielsen A, Humaidan P, Erb K, Ernst E, Loft A. Malformation rate and sex ratio in 412 children conceived with epididymal or testicular sperm. Human Reproduction. 2007; 22: 1080–1085.

[22] Oates RD, Amos JA. The genetic basis of congenital bilateral absence of the vas deferens and cystic fibrosis. Journal of Andrology. 1994; 15: 1–8.

[23] Buffat C, Patrat C, Merlet F, Guibert J, Epelboin S, Thiounn N, et al. ICSI outcomes in obstructive azoospermia: influence of the origin of surgically retrieved spermatozoa and the cause of obstruction. Human Reproduction. 2006; 21: 1018–1024.

[24] Esteves SC, Roque M, Bedoschi G, Haahr T, Humaidan P. Intracy-toplasmic sperm injection for male infertility and consequences for offspring. Nature Reviews Urology. 2018; 15: 535–562.

[25] Wang H, An M, Liu Y, Hu K, Jin Y, Xu S, et al. Genetic diagnosis and sperm retrieval outcomes for Chinese patients with congenital bilateral absence of vas deferens. Andrology. 2020; 8: 1064–1069.

[26] He X, Cao Y, Zhang Z, Zhao J, Wei Z, Zhou P, et al. Spermatogenesis affects the outcome of ICSI for azoospermic patients rather than sperm retrieval method. Systems Biology in Reproductive Medicine. 2010; 56: 457–464.

[27] Veleva Z, Orava M, Nuojua-Huttunen S, Tapanainen JS, Martikainen H. Factors affecting the outcome of frozen-thawed embryo transfer. Human Reproduction. 2013; 28: 2425–2431.

[28] Reljič M, Knez J, Kovač V, Kovačič B. Endometrial injury, the quality of embryos, and blastocyst transfer are the most important prognostic factors for in vitro fertilization success after previous repeated unsuccessful attempts. Journal of Assisted Reproduction and Genetics. 2017; 34: 775–779.

[29] Setti A, Halpern G, Braga D, Figueira R, Iaconelli A, Borges E. Association between parental anthropometric measures and the out-comes of intracytoplasmic sperm injection cycles. Journal of Assisted Reproduction and Genetics. 2019; 36: 461–471.

[30] Nicopoullos JDM, Gilling-Smith C, Almeida PA, Ramsay JWA. The results of 154 ICSI cycles using surgically retrieved sperm from azoospermic men. Human Reproduction. 2004; 19: 579–585.

[31] Akinsal EC, Baydilli N, Dogan ME, Ekmekcioglu O. Comorbidity of the congenital absence of the vas deferens. Andrologia. 2018. (in press)

[32] Yang B, Wang X, Zhang W, Li H, Wang B. Compound heterozygous mutations in CFTR causing CBAVD in Chinese pedigrees. Molecular Genetics & Genomic Medicine. 2018; 6: 1097–1103.

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