Fertility outcome of patients with CBAVD: a single-institution experience
1Department of Urology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, 100730 Beijing, China
2Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, 100730 Beijing, China
3Department of Medical Genetics and Developmental Biology, School of Basic Medical Sciences, Capital Medical University, 100069 Beijing, China
4Center for Genetics, National Research Institute for Family Planning, 100081 Beijing, China
Submitted: 28 July 2021 Accepted: 09 September 2021
Online publish date: 16 September 2021
Background and objective: Congenital bilateral absence of the vas deferens (CBAVD) is not common and fertility outcome is not clear. This study is to report fertility outcomes of infertile male with CBAVD.
Material and methods: Our study cohort comprised CBAVD males who were enrolled from 2005 to 2019. Baseline information was collected including mean age, previous medical history, duration of infertility, sex hormone assays, ejaculate volume/pH, parameters of sperm retrieved by percutaneous epididymal sperm aspiration (PESA), development of seminal vesicle TRUS, follow up fertility outcomes of the patients with Intracytoplasmic sperm injection (ICSI)and compared the impact of varies male factors on fertility outcomes.
Results: 172 participants with CBAVD were analyzed. A total of 211 ICSI cycles were performed and the live birth rate was 46.92%. Among 126 live births, 57 (45.24%) were boy and 69 (54.76%) were girl. The neonatal weight and height are 3036.83 ± 672.17 g, 49.43 ± 2.49 cm, respectively. There were no significant differences between successes group of couples and fail group of couples for first ICSI cycles cases in terms of age (P = 0.09), testicle volume (left P = 0.96, right P = 0.41), sex hormones (P > 0.05), ejaculate volume (P = 0.79), ejaculate pH (P = 0.78) or sperm quality parameters from PESA (P > 0.05). Conclusions: This study indicates that the clinical characteristics of male with CBAVD had no impact on fertility outcomes.
Male infertility; CBAVD; Fertility outcome; Percutaneous epididymal sperm aspiration; Intracytoplasmic sperm injection
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