Article Data

  • Views 255
  • Dowloads 126

Case Report

Open Access

Retrograde ejaculation as an initial presenting symptom of type 2 diabetes mellitus: a case report and literature review

  • Yu-Shan Mao1
  • Ning-Jun Fang2
  • Zhi-Ren Sheng1
  • Yi-Feng Mai1

1Department of Endocrinology, the Affiliated Hospital of Medical School, Ningbo University, 315020 Ningbo, Zhejiang, China

2Department of Urology, the Affiliated Hospital of Medical School, Ningbo University, 315020 Ningbo, Zhejiang, China

DOI: 10.31083/jomh.2021.114

Submitted: 13 July 2021 Accepted: 25 August 2021

Online publish date: 10 September 2021

*Corresponding Author(s): Yu-Shan Mao E-mail: maoyushan@nbu.edu.cn

PDF (74.74 kB)

Abstract

Retrograde ejaculation (RE), known as one of the late complications of diabetes mellitus, is rarely a presenting symptom in the diagnosis of diabetes. A 30-year-old male presented with a progressive decline in ejaculate over 2-month. Lab results revealed a high random blood glucose level (425 mg/dL). A substantial number of sperm were found in the post-ejaculate urine specimens, confirming a diagnosis of RE. Further lab tests revealed an hemoglobin-A1c (HbA1c) of 12.7%, with negative results for antibodies to glutamic acid decarboxylase, insulin antigen-2, insulin receptor and islet cell, consistent with a diagnosis of type 2 diabetes mellitus (T2DM). Insulin glargine and oral anti-hyperglycemic agents were initiated. Also, imipramine and pseudoephedrine were prescribed for 4-week and then discontinued, as no positive effect on ejaculation was seen. At the 36-month follow-up, the patient had a normal glucose level with HbA1c <6.5%. However, RE persisted. RE is commonly seen as a late-stage complication among T2DM. We presented a rare case where RE was the first referred symptom of T2DM and RE persisted even after adequate control of glycemia.

Keywords

Retrograde ejaculation; Type 2 diabetes mellitus; Complication; Case report

Cite and Share

Yu-Shan Mao,Ning-Jun Fang,Zhi-Ren Sheng,Yi-Feng Mai. Retrograde ejaculation as an initial presenting symptom of type 2 diabetes mellitus: a case report and literature review. Journal of Men's Health. 2021.doi:10.31083/jomh.2021.114.

References

[1] Parnham A, Serefoglu EC. Retrograde ejaculation, painful ejaculation and hematospermia. Translational Andrology and Urology. 2016; 5: 592–601.

[2] Fedder J, Kaspersen MD, Brandslund I, Højgaard A. Retrograde ejaculation and sexual dysfunction in men with diabetes mellitus: a prospective, controlled study. Andrology. 2013; 1: 602–606.

[3] Verrotti A, Prezioso G, Scattoni R, Chiarelli F. Autonomic neuropathy in diabetes mellitus. Frontiers in Endocrinology. 2014; 5: 205.

[4] Mostafa T, Abdel-Hamid IA. Ejaculatory dysfunction in men with diabetes mellitus. World Journal of Diabetes. 2021; 12: 954–974.

[5] Ibragimov AZ, Aliev TA, AbdullaevKI, Mirza-Zade VA. The function of the closure apparatus of the bladder in retrograde ejaculation in diabetics. Urologiia i Nefrologiia. 1990; 3: 65–68.

[6] Gaunay G, Nagler HM, Stember DS. Reproductive Sequelae of Diabetes in Male Patients. Endocrinology and Metabolism Clinics of North America. 2013; 42: 899–914.

[7] Kam J, Tsang VH, Chalasani V. Retrograde Ejaculation: a Rare Presenting Symptom of Type 1 Diabetes Mellitus. Urology Case Reports. 2016; 10: 9–10.

[8] Arafa M, El Tabie O. Medical Treatment of Retrograde Ejaculation in Diabetic Patients: a Hope for Spontaneous Pregnancy. The Journal of Sexual Medicine. 2008; 5: 194–198.

Abstracted / indexed in

Science Citation Index Expanded Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,200 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Social Sciences Citation Index Social Sciences Citation Index contains over 3,400 journals across 58 social sciences disciplines, as well as selected items from 3,500 of the world’s leading scientific and technical journals. More than 9.37 million records and 122 million cited references date back from 1900 to present.

Current Contents - Social & Behavioral Sciences Current Contents - Social & Behavioral Sciences provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in the social and behavioral sciences.

Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.

SCOPUS Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.

DOAJ DOAJ is a community-curated online directory that indexes and provides access to high quality, open access, peer-reviewed journals.

CrossRef Crossref makes research outputs easy to find, cite, link, assess, and reuse. Crossref committed to open scholarly infrastructure and collaboration, this is now announcing a very deliberate path.

Portico Portico is a community-supported preservation archive that safeguards access to e-journals, e-books, and digital collections. Our unique, trusted process ensures that the content we preserve will remain accessible and usable for researchers, scholars, and students in the future.

Submission Turnaround Time

Conferences

    Top