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Assessment of semen parameters and Anti-müllerian hormone level in patients with chronic kidney disease on hemodialysis: a case control study

  • Rashad Mostafa1
  • Ghada M. Soliman2
  • Amal F. Abd Alhai3
  • Mohamed Azab4

1Andrology, Sexology and STDS Department, Faculty of Medicine, Suez Canal University, 41511 Ismailia, Egypt

2Ministry of Health and Population, Etsa Medical Center, 63759 Fayoum, Egypt

3Clinical Pathology Department, Faculty of Medicine, Suez Canal University, 41511 Ismailia, Egypt

4Andrology, Infertility and STDS Department, Faculty of Medicine, Suez Canal University, 41511 Ismailia, Egypt

DOI: 10.31083/jomh.2021.074 Vol.17,Issue 4,September 2021 pp.72-77

Submitted: 28 April 2021 Accepted: 02 July 2021

Published: 30 September 2021

*Corresponding Author(s): Mohamed Azab E-mail:

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Background and objective: Chronic kidney disease (CKD) is a common health problem which is accompanied by considerable morbidity and mortality. Anti-müllerian hormone (AMH) is one of the hormones that are affected by CKD. The objective was to assess semen parameters and AMH level in CKD patients on hemodialysis.

Material and methods: This study was a case control study of 20 patients with stage 4 and 5 CKD on hemodialysis, attending Nephrology Outpatient Clinic and Renal Dialysis Unit of Suez Canal University hospital and 20 healthy fertile controls. Full history, clinical examination, kidney function tests and semen analysis were performed. AMH level in serum and seminal plasma was measured using ELISA.

Results: The mean AMH level in serum of case group was 3.35 ± 2.43 ng/mL versus 4.13 ± 3.17 ng/mL in the controls respectively (p > 0.05) while mean AMH level in semen of the case group was 2.13 ± 2.64 ng/mL compared to 9.37 ± 3.79 ng/mL in controls respectively (p < 0.05). There was a positive correlation between AMH in seminal plasma and sperm count, total sperm motility, progressive sperm motility and sperm viability, while the AMH level in serum was insignificantly related.

Conclusion: Semen parameters in CKD patients on hemodialysis were significantly poorer than normal controls AMH in seminal plasma was significantly decreased in CKD patients (stage 4–5 on hemodialysis) and significantly correlated with the semen parameters.


CKD; Serum AMH; Seminal AMH; Semen parameters

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Rashad Mostafa,Ghada M. Soliman,Amal F. Abd Alhai,Mohamed Azab. Assessment of semen parameters and Anti-müllerian hormone level in patients with chronic kidney disease on hemodialysis: a case control study. Journal of Men's Health. 2021. 17(4);72-77.


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