Assessment of semen parameters and Anti-müllerian hormone level in patients with chronic kidney disease on hemodialysis: a case control study
1Andrology, Sexology and STDS Department, Faculty of Medicine, Suez Canal University, 41511 Ismailia, Egypt
2Ministry of Health and Population, Etsa Medical Center, 63759 Fayoum, Egypt
3Clinical Pathology Department, Faculty of Medicine, Suez Canal University, 41511 Ismailia, Egypt
4Andrology, Infertility and STDS Department, Faculty of Medicine, Suez Canal University, 41511 Ismailia, Egypt
Submitted: 28 April 2021 Accepted: 02 July 2021
Online publish date: 19 July 2021
Background and Objective: Chronic kidney disease (CKD) is a common health problem which is accompanied by considerable morbidity and mortality. Anti-müllerian hormone (AMH) is one of the hormones that are affected by CKD. The objective was to assess semen parameters and AMH level in CKD patients on hemodialysis.
Material and methods: This study was a case control study of 20 patients with stage 4 and 5 CKD on hemodialysis, attending Nephrology Outpatient Clinic and Renal Dialysis Unit of Suez Canal University hospital and 20 healthy fertile controls. Full history, clinical examination, kidney function tests and semen analysis were performed. AMH level in serum and seminal plasma was measured using ELISA.
Results: The mean AMH level in serum of case group was 3.35 ± 2.43 ng/mL versus 4.13 ± 3.17 ng/mL in the controls respectively (p > 0.05) while mean AMH level in semen of the case group was 2.13 ± 2.64 ng/mL compared to 9.37 ± 3.79 ng/mL in controls respectively (p < 0.05). There was a positive correlation between AMH in seminal plasma and sperm count, total sperm motility, progressive sperm motility and sperm viability, while the AMH level in serum was insigniﬁcantly related.
Conclusion: Semen parameters in CKD patients on hemodialysis were signiﬁcantly poorer than normal controls AMH in seminal plasma was signiﬁcantly decreased in CKD patients (stage 4–5 on hemodialysis) and signiﬁcantly correlated with the semen parameters.
CKD; Serum AMH; Seminal AMH; Semen parameters
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