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Systematic review

Open Access Special Issue

Insights into association between urolithiasis and prostate cancer

  • Xiaolu Sun1,†
  • Bhuman Deep Kour2,3,4,†
  • Xiangtao Wang1
  • Xiufang Hu5
  • Yufen Wang6
  • Sugunakar Vuree2,4

1Department of Urology, Shandong Provincial Third Hospital, Shandong University, 250031 Jinan, China

2Department of Biotechnology, School of Bioengineering and Biosciences Lovely Professional University, 144111 Punjab, India

3Department of Biotechnology and Bioinformatics, Birla Institute of Scientific Research (BISR), 302021 Rajasthan, India

4BIOinformatics CLUb for Experimenting Scientists (, India

5Department of Internal medicine, The People Hospital of Huaiyin, 250021 Jinan, China

6Department of Padiatric, Shandong Provincial Third Hospital, Shandong University, 250031 Jinan, China

DOI: 10.31083/jomh.2021.070 Vol.17,Issue 4,September 2021 pp.52-61

Submitted: 24 January 2021 Accepted: 04 March 2021

Published: 30 September 2021

*Corresponding Author(s): Yufen Wang E-mail:
*Corresponding Author(s): Sugunakar Vuree E-mail:

† These authors contributed equally.

PDF (1.56 MB) Supplementary material


Background and objective: Urolithiasis or renal stones form a major urinary tract infection with formation of calcifications in the bladder and uterus. With the lifestyle diseases burgeoning, the renal stones have become a common cause with an approximate 1 in 1000 people affected all over the world with a risk ratio of 3 : 1 in men and women. On the other hand, prostate or genitourinary cancers are well documented to be associated with urolithiasis.

Methods: A gene list was prepared from the published NCBI dataset, comprising all the genes related to urolithiasis primarily with mutations (both pathogenic and likely pathogenic Single nucleotide polymorphisms, SNP's) for every particular gene screened later from the published datasets. To see the interactions among all the potential genetic factors, PPI based tools were used and an interaction map was prepared. For the characterization of mutations, we have used gnomAD for verifying all the SNPs whether they are synonymous or nonsynonymous mutations.

Results: We outlined the list of genes and discussed the systems bioinformatics integrated approach associated with it.

Conclusion: We found a large number of genes common to them and their association is subtly known for immunomodulatory response.


Urolithiasis; Genitourinary cancer; Prostate cancer; Renal/kidney stones; Hyperuricemia; Calcium homeostasis

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Xiaolu Sun,Bhuman Deep Kour,Xiangtao Wang,Xiufang Hu,Yufen Wang,Sugunakar Vuree. Insights into association between urolithiasis and prostate cancer. Journal of Men's Health. 2021. 17(4);52-61.


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