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The 100 most-cited articles in castration-resistant prostate cancer: a bibliometric analysis

  • Hui Fang1,2,†
  • Lugeng He3,†
  • Huadong He3
  • Xuliang Wang3
  • Yuyong Wang3
  • Hongwei Ge3
  • Yuehua Wan1,2,†
  • Chao Chen3,†

1Institute of Information Resource, Zhejiang University of Technology, 310014 Hangzhou, China

2Library, Zhejiang University of Technology, 310014 Hangzhou, China

3Department of Urology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, 310006 Hangzhou, China

DOI: 10.31083/jomh.2021.053

Submitted: 23 February 2021 Accepted: 09 March 2021

Online publish date: 18 June 2021

*Corresponding Author(s): Yuehua Wan E-mail:
*Corresponding Author(s): Chao Chen E-mail:

† These authors contributed equally.

PDF (2.66 MB) Supplementary material


Purpose: To assess the present landscape and future research directions, a bibliometric analysis was performed to identify the characteristics of the 100 most-cited articles (T100 articles) on CRPC research.

Methods: A list of the T100 articles investigating CRPC was generated by searching the Web of Science (WoS) Core Collection database. Different characteristics of the T100 articles, including the countries/territories, journals, authors, and research areas, were analyzed.

Results: The number of citations of T100 articles published between 1992 and 2017 ranged from 282 to 3594, with an average of 654.9 citations. According to the topic of the article, ''Mechanisms related to tumor progression or metastasis'' ranked first with 41 T100 articles, while immunotherapy ranked fourth with 7 T100 articles. The T100 articles originated from 31 countries, with more than half originating from the USA (n = 89). Professor Scher HI published the most T100 articles as the first author (4) and as the corresponding author (5), while Pro De Bono JS from the Institute of Cancer Research published 3 articles as the first author and 8 articles as the corresponding author. The journal Cancer Research published 20 T100 articles with a total of 8946 citations. The number of T100 articles(r = 0.485, P = 0.01) and the total number of citations(r = 0.626, P < 0.001) were all positively correlated with the IF of the journal.

Conclusions: This analysis offers a historical perspective on the progress and attempts to reveal future trends in CRPC research using bibliometric analysis. This study's results suggest that immunotherapy and the study of androgen receptors as well as their signaling axes will possibly be hot topics and trends in CRPC research.


Castration-resistant prostate cancer (CRPC); Mechanism; Tumor progression; Metastasis; Immunotherapy; Bibliometric analysis

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Hui Fang,Lugeng He,Huadong He,Xuliang Wang,Yuyong Wang,Hongwei Ge,Yuehua Wan,Chao Chen. The 100 most-cited articles in castration-resistant prostate cancer: a bibliometric analysis. Journal of Men's Health. 2021.doi:10.31083/jomh.2021.053.


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