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Open Access Special Issue

Takotsubo syndrome, neurological disorders, and sex: a dangerous liaison?

  • Rosaria Cappadona1,†
  • Roberto Manfredini1

1Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy

DOI: 10.31083/jomh.2021.050 Vol.17,Issue 3,July 2021 pp.1-3

Submitted: 17 May 2021 Accepted: 03 June 2021

Published: 08 July 2021

*Corresponding Author(s): Roberto Manfredini E-mail:

† These authors contributed equally.

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Takotsubo syndrome; Outcome; Sex; Gender; In-hospital mortality; Neurological disorders; Stroke; Subarachnoid hemorrhage; Intracerebral hemorrhage; Death

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Rosaria Cappadona,Roberto Manfredini. Takotsubo syndrome, neurological disorders, and sex: a dangerous liaison?. Journal of Men's Health. 2021. 17(3);1-3.


[1] Ghadri JR, Wittstein IS, Prasad A, Sharkey S, Dote K, Akashi YJ, et al. International Expert Consensus Document on Takotsubo Syndrome (Part I): Clinical Characteristics, Diagnostic Criteria, and Pathophysiology. European Heart Journal. 2018; 39: 2032–2046.

[2] Manfredini R, Cappadona R, Fabbian F. Is Takotsubo Syndrome still a Benign Disease? Complications (and Gender) Make the Difference. Angiology. 2019; 70: 795–796.

[3] Stiermaier T, Moeller C, Oehler K, Desch S, Graf T, Eitel C, et al. Long-term excess mortality in takotsubo cardiomyopathy: predictors, causes and clinical consequences. European Journal of Heart Failure. 2016; 18: 650–656.

[4] Lemor A, Ramos-Rodriguez AJ, De La Villa R, Hosseini Dehkordi SH, Vazquez de Lara F, Lee S, et al. Impact of gender on in—hospital outcomes in patients with Takotsubo syndrome: a nationwide analysis from 2006 to 2014. Clinical Cardiology. 2019; 42: 13–18.

[5] Pérez-Castellanos A, Martínez-Sellés M, Mejía-Rentería H, Andrés M, Sionis A, Almendro-Delia M, et al. Tako-tsubo Syndrome in Men: Rare, but with Poor Prognosis. Revista Espanola De Cardiologia. 2017; 71: 703–708.

[6] Lau C, Chiu S, Nayak R, Lin B, Lee MS. Survival and risk of recurrence of takotsubo syndrome. Heart. 2021; heartjnl-2020-318028.

[7] Virani SS, Alonso A, Aparicio HJ, Benjamin EJ, Bittencourt MS, Callaway CW, et al. Heart Disease and Stroke Statistics-2021 Update: A Report From the American Heart Association. Circulation. 2021; 143: e254–e743.

[8] Citro R, Previtali M, Bovelli D, Vriz O, Astarita C, Patella MM, et al. Chronobiological Patterns of Onset of Tako-Tsubo Cardiomyopathy: a multicenter Italian study. Journal of the American College of Cardiology. 2009; 54: 180–181.

[9] Manfredini R, Boari B, Smolensky MH, Salmi R, la Cecilia O, Maria Malagoni A, et al. Circadian variation in stroke onset: identical temporal pattern in ischemic and hemorrhagic events. Chronobiology International. 2005; 22: 417–453.

[10] Manfredini R, Citro R, Previtali M, Vriz O, Ciampi Q, Pascotto M, et al. Monday preference in onset of takotsubo cardiomyopathy. The American Journal of Emergency Medicine. 2010; 28: 715–719.

[11] Manfredini R, Casetta I, Paolino E, la Cecilia O, Boari B, Fallica E, et al. Monday preference in onset of ischemic stroke. the American Journal of Medicine. 2001; 111: 401–403.

[12] Templin C, Ghadri JR, Diekmann J, Napp LC, Bataiosu DR, Ja-guszewski M, et al. Clinical Features and Outcomes of Takotsubo (Stress) Cardiomyopathy. The New England Journal of Medicine. 2015; 373: 929–938.

[13] Elgendy AY, Elgendy IY, Mansoor H, Mahmoud AN. Clinical presentations and outcomes of Takotsubo syndrome in the setting of subarachnoid hemorrhage: a systematic review and meta-analysis. European Heart Journal Acute Cardiovascular Care. 2018; 7: 236–245.

[14] Morris NA, Chatterjee A, Adejumo OL, Chen M, Merkler AE, Murthy SB, et al. The Risk of Takotsubo Cardiomyopathy in Acute Neurological Disease. Neurocritical Care. 2019; 30: 171–176.

[15] Jung JM, Kim JG, Kim JB, Cho K, Yu S, Oh K, et al. Takotsubo-Like Myocardial Dysfunction in Ischemic Stroke: a Hospital-Based Registry and Systematic Literature Review. Stroke. 2016; 47: 2729–2736.

[16] Abanador-Kamper N, Kamper L, Wolfertz J, Vorpahl M, Haage P, Seyfarth M. Temporarily increased stroke rate after Takotsubo syn-drome: need for an anticoagulation? BioMed Central Cardiovascular Disorders. 2018; 18: 117.

[17] Santoro F, Stiermaier T, Guastafierro F, Tarantino N, Eitel I, Brunetti ND. Oral anticoagulation in high risk Takotsubo syndrome: when should it be considered and when not? BioMed Central Cardiovascular Disorders. 2019; 18: 205.

[18] Jurisic S, Gili S, Cammann VL, Kato K, Szawan KA, D’Ascenzo F, et al. Clinical predictors and prognostic impact of recovery of wall motion abnormalities in Takotsubo syndrome: results from the International Takotsubo Registry. Journal of the American Heart Association. 2019; 8: e011194.

[19] Santoro F, Núñez Gil IJ, Stiermaier T, El-Battrawy I, Guerra F, Novo G, et al. Assessment of the German and Italian Stress Cardiomyopathy Score for Risk Stratification for in-hospital Complications in Patients with Takotsubo Syndrome. The Journal of the American Medical Association Cardiology. 2019; 4: 892–899.

[20] Lorber J, Moore LJ. Gender and the Social Construction of Illness. 2nd edn. Plymouth, United Kingdom: AltaMira Press. 2002.

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