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Original Research

Open Access Special Issue

Cerebral blood flow velocity is associated with endothelial function in men

  • Nobuhiko Akazawa1,2
  • Hiroshi Kumagai3
  • Toru Yoshikawa4
  • Kanae Myoenzono5,6
  • Koichiro Tanahashi7
  • Seiji Maeda1,8

1Faculty of Health and Sport Sciences, University of Tsukuba, 305-8574 Tsukuba, Ibaraki, Japan

2Department of Sports Research, Japan Institute of Sports Sciences, 105-0056 Kita-ku, Tokyo, Japan

3The Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA

4Faculty of Health and Sport Sciences, Ryutsu Keizai University, 301-8555 Ryugasaki, Ibaraki, Japan

5Graduates School of Comprehensive Human Sciences, University of Tsukuba, 305-8574 Tsukuba, Ibaraki, Japan

6Humanome Lab Inc., 104-0045 Chuo-ku, Tokyo, Japan

7Department of Health and Sports Sciences, Kyoto Pharmaceutical University, 607-8414 Kyoto, Kyoto, Japan

8Faculty of Sport Sciences, Waseda University, 359-1192 Tokorozawa, Saitama, Japan

DOI: 10.31083/jomh.2021.049 Vol.17,Issue 3,July 2021 pp.41-46

Submitted: 23 April 2021 Accepted: 01 June 2021

Published: 08 July 2021

*Corresponding Author(s): Seiji Maeda E-mail:

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Background and objective: Reduction in cerebral blood flow with aging leads to cognitive decline and brain atrophy. Cerebrovascular hemodynamics are associated with vascular function. However, little is known about endothelial function in relation to cerebral blood flow at rest. The present study aimed to examine the association between microvascular endothelial function and middle cerebral blood flow.

Material and methods: This study involved 60 healthy middle-aged and elderly men. The microvascular endothelial function was measured via digital reactive hyperemia index using pulse amplitude tonometry, and the mean middle cerebral blood flow velocity and cerebrovascular conductance were measured using transcranial Doppler ultrasonography.

Results and conclusions: Reactive hyperemia index was significantly correlated with the mean middle cerebral blood flow velocity and cerebrovascular conductance. Multiple regression analysis further indicated that the correlation was significant after adjustment of covariates, such as age, body mass index, smoking status, medication history, blood pressure, and arterial stiffness. Further, Reactive hyperemia index was found to be a significant independent determinant of the mean middle cerebral blood flow velocity and cerebrovascular conductance. The present study demonstrated that vascular endothelial function is associated with cerebral blood flow and is an independent potential confounding factor in healthy middle-aged and older men.


Vascular function; Brain; Blood flow

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Nobuhiko Akazawa,Hiroshi Kumagai,Toru Yoshikawa,Kanae Myoenzono,Koichiro Tanahashi,Seiji Maeda. Cerebral blood flow velocity is associated with endothelial function in men. Journal of Men's Health. 2021. 17(3);41-46.


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