Mechanisms of castration resistant prostate cancer formation and progression through neuroendocrine differentiation
1Department of Urology, the Second Aﬃliated Hospital of Bengbu Medical College, 233020 Bengbu, Anhui, China
Submitted: 02 March 2021 Accepted: 22 March 2021
Online publish date: 20 May 2021
Normal prostate tissues consist mainly of epithelial cells, including secretory epithelial cells, basal cells, and neuroendocrine cells, and of mesenchymal cells, including smooth muscle cells and ﬁbroblasts. The mechanisms leading to castration resistant prostate cancer (CRPC) are complex and diverse, but most involve neuroendocrine differentiation. In fact, during the development of prostate cancer, some of the tumor cells transform into neuroendocrine-like cells. This transition is a main underlying mechanism of CRPC formation.
Prostate cancer; Neuroendocrine differentiation; Castration resistance prostate cancer
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