Effects of psoriasis and metabolic syndrome on male sexual functions
1Department of Urology, Faculty of Medicine, Cumhuriyet University, 41400 Sivas, Turkey
2Department of Dermatology, Faculty of Medicine, Cumhuriyet University, 41400 Sivas, Turkey
3Department of Internal Medicine, Faculty of Medicine, Cumhuriyet University, 41400 Sivas, Turkey
Submitted: 15 February 2021 Accepted: 04 March 2021
Online publish date: 13 May 2021
Background and Objective: Psoriasis is a chronic inﬂammatory systemic skin disease triggered by psychological, genetic and environmental factors. The effect of psoriasis on sexual health has not been fully elucidated. Coexistence of psychiatric disorders also affects negatively the life quality of psoriasis patients. This study investigates the relationship between the severity of the current illness, psychosocial health problems and coexisting metabolic syndrome on sexual health in male patients with psoriasis.
Materials and methods: 52 male patients diagnosed with psoriasis and 50 healthy men included for the study. Patient groups Psoriasis Area Severity Index (PASI) and The Dermatology Life Quality Index (DLQI) were tested, subsequently International Index of Erectile Function (IIEF), Hamilton Rating Scale for Depression (HAM-D) tests and Metabolic syndrome (MetS) were reported for both groups. Eventually, the patient groups treaments were recorded.
Results: IIEF, HAM-D scores and MetS were signiﬁcantly different between the two groups (P = 0.017, P = 0.005, P = 0.009). IIEF score had a signiﬁcant negative correlation with age, HAM-D and PASI scores (r = –0.405, –0.217 and –0.394, P = 0.028, 0.043 and 0.014). It is seen that the frequency and severity of ED increased with methotrexate treatment.
Conclusion: It is showed that psoriasis has negative effects on male sexual health in this study. Our opinion of the reason is the natural course of the disease, its coexistence with diseases such as metabolic syndrome and depression, and the agents used in its treatment.
Psoriasis; Erectile dysfunction; Metabolic syndrome
Hüseyin Saygın,Mustafa Tosun,Abuzer Öztürk,İsmail Emre Ergin,Emre Kıraç,Aydemir Asdemir,Arslan Fatih Velibeyoğlu,Ahmet Aktaş,Esat Korgalı. Effects of psoriasis and metabolic syndrome on male sexual functions. Journal of Men's Health. 2021.doi:10.31083/jomh.2021.038.
 World Health Organization. Global report on psoriasis. 2016. Avali-able at: https://apps.who.int/iris/handle/10665/204417 (Accessed: 13 January 2021).
 Davidovici BB, Sattar N, Prinz JC, Jörg PC, Puig L, Emery P, et al. Psoriasis and systemic inflammatory diseases: potential mechanistic links between skin disease and co-morbid conditions. Journal of Investigative Dermatology. 2010; 130: 1785–1796.
 Lasker GF, Maley JH, Kadowitz PJ. A review of the pathophysiology and novel treatments for erectile dysfunction. Advances in Pharmaco-logical Sciences. 2010; 2010: 730861.
 Gupta MA, Gupta AK. Psoriasis and sex: a study of moderately to severely affected patients. International Journal of Dermatology. 1997; 36: 259–262.
 Meeuwis KAP, de Hullu JA, van de Nieuwenhof HP, Evers AWM, Massuger LFAG, van de Kerkhof PCM, et al. Quality of life and sexual health in patients with genital psoriasis. British Journal of Dermatology. 2011; 164: 1247–1255.
 Wojciechowska-Zdrojowy M, Reich A, Szepietowski JC, Woj-ciechowski A. Analysis of sexual problems in men with psoriasis. Journal of Sex & Marital Therapy. 2018; 44: 737–745.
 Bell KA, Balogh EA, Feldman SR. An update on the impact of depression on the treatment of psoriasis. Expert Opin Pharmacother. 2021; 22: 695–703. (in press)
 Russo PA, Ilchef R, Cooper AJ. Psychiatric morbidity in psoriasis: a review. Australasian Journal of Dermatology. 2004; 45: 155–159.
 Wu JJ, Feldman SR, Koo J, Marangell LB. Epidemiology of mental health comorbidity in psoriasis. Journal of Dermatological Treatment. 2018; 29: 487–495.
 Cabete J, Torres T, Vilarinho T, Ferreira A, Selores M. Erectile dysfunction in psoriasis patients. European Journal of Dermatology. 2014; 24: 482–486.
 Chen Y, Chen C, Lin M, Chen T, Li C, Hwang C, et al. Increased risk of sexual dysfunction in male patients with psoriasis: a nationwide population-based follow-up study. Journal of Sexual Medicine. 2013; 10: 1212–1218.
 Wylie G, Evans CD, Gupta G. Reduced libido and erectile dysfunction: rarely reported side-effects of methotrexate. Clinical and Experimental Dermatology. 2009; 34: e234.
 Aguirre MA, Vélez A, Romero M, Collantes E. Gynecomastia and sexual impotence associated with methotrexate treatment. The Journal of Rheumatology. 2002; 29: 1793–1794.
 Cemil BC, Cengiz FP, Atas H, Ozturk G, Canpolat F. Sex hormones in male psoriasis patients and their correlation with the Psoriasis Area and Severity Index. Journal of Dermatology. 2015; 42: 500–503.
 Özer İ, Temiz SA, Ataseven A, Dursun R, Uyar M, Özer M. Is prenatal testosterone-estrogen balance associated with psoriasis? Dermatologic Therapy. 2020; 33: e14213.
 Bardazzi F, Odorici G, Ferrara F, Magnano M, Balestri R, Patrizi A. Sex and the PASI: patients affected by a mild form of psoriasis are more predisposed to have a more severe form of erectile dysfunction. Journal of the European Academy of Dermatology and Venereology. 2016; 30: 1342–1348.
 Ji S, Zang Z, Ma H, Gu M, Han Y, Wang L, et al. Erectile dysfunction in patients with plaque psoriasis: the relation of depression and cardiovascular factors. International Journal of Impotence Research. 2016; 28: 96–100.
 Ardahanlı İ, Celik M. Can myocardial performance index predict early cardiac risks in erectile dysfunction? Aging Male. 2020; 1–7.
Science Citation Index Expanded Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,200 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.
Social Sciences Citation Index Social Sciences Citation Index contains over 3,400 journals across 58 social sciences disciplines, as well as selected items from 3,500 of the world’s leading scientific and technical journals. More than 9.37 million records and 122 million cited references date back from 1900 to present.
Current Contents - Social & Behavioral Sciences Current Contents - Social & Behavioral Sciences provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in the social and behavioral sciences.
Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.
SCOPUS Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.
DOAJ DOAJ is a community-curated online directory that indexes and provides access to high quality, open access, peer-reviewed journals.
CrossRef Crossref makes research outputs easy to find, cite, link, assess, and reuse. Crossref committed to open scholarly infrastructure and collaboration, this is now announcing a very deliberate path.
Portico Portico is a community-supported preservation archive that safeguards access to e-journals, e-books, and digital collections. Our unique, trusted process ensures that the content we preserve will remain accessible and usable for researchers, scholars, and students in the future.