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Original Research

Open Access Special Issue

Effects of psoriasis and metabolic syndrome on male sexual functions

  • Hüseyin Saygın1
  • Mustafa Tosun2
  • Abuzer Öztürk1
  • İsmail Emre Ergin1
  • Emre Kıraç1
  • Aydemir Asdemir1
  • Arslan Fatih Velibeyoğlu1
  • Ahmet Aktaş3
  • Esat Korgalı1

1Department of Urology, Faculty of Medicine, Cumhuriyet University, 41400 Sivas, Turkey

2Department of Dermatology, Faculty of Medicine, Cumhuriyet University, 41400 Sivas, Turkey

3Department of Internal Medicine, Faculty of Medicine, Cumhuriyet University, 41400 Sivas, Turkey

DOI: 10.31083/jomh.2021.038 Vol.17,Issue 3,July 2021 pp.91-95

Submitted: 15 February 2021 Accepted: 04 March 2021

Published: 08 July 2021

*Corresponding Author(s): Ahmet Aktaş E-mail: ahmetaktas0142@hotmail.com

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Abstract

Background and Objective: Psoriasis is a chronic inflammatory systemic skin disease triggered by psychological, genetic and environmental factors. The effect of psoriasis on sexual health has not been fully elucidated. Coexistence of psychiatric disorders also affects negatively the life quality of psoriasis patients. This study investigates the relationship between the severity of the current illness, psychosocial health problems and coexisting metabolic syndrome on sexual health in male patients with psoriasis.

Materials and methods: 52 male patients diagnosed with psoriasis and 50 healthy men included for the study. Patient groups Psoriasis Area Severity Index (PASI) and The Dermatology Life Quality Index (DLQI) were tested, subsequently International Index of Erectile Function (IIEF), Hamilton Rating Scale for Depression (HAM-D) tests and Metabolic syndrome (MetS) were reported for both groups. Eventually, the patient groups treaments were recorded.

Results: IIEF, HAM-D scores and MetS were significantly different between the two groups (P = 0.017, P = 0.005, P = 0.009). IIEF score had a significant negative correlation with age, HAM-D and PASI scores (r = –0.405, –0.217 and –0.394, P = 0.028, 0.043 and 0.014). It is seen that the frequency and severity of ED increased with methotrexate treatment.

Conclusion: It is showed that psoriasis has negative effects on male sexual health in this study. Our opinion of the reason is the natural course of the disease, its coexistence with diseases such as metabolic syndrome and depression, and the agents used in its treatment.

Keywords

Psoriasis; Erectile dysfunction; Metabolic syndrome

Cite and Share

Hüseyin Saygın,Mustafa Tosun,Abuzer Öztürk,İsmail Emre Ergin,Emre Kıraç,Aydemir Asdemir,Arslan Fatih Velibeyoğlu,Ahmet Aktaş,Esat Korgalı. Effects of psoriasis and metabolic syndrome on male sexual functions. Journal of Men's Health. 2021. 17(3);91-95.

References

[1] World Health Organization. Global report on psoriasis. 2016. Avali-able at: https://apps.who.int/iris/handle/10665/204417 (Accessed: 13 January 2021).

[2] Davidovici BB, Sattar N, Prinz JC, Jörg PC, Puig L, Emery P, et al. Psoriasis and systemic inflammatory diseases: potential mechanistic links between skin disease and co-morbid conditions. Journal of Investigative Dermatology. 2010; 130: 1785–1796.

[3] Lasker GF, Maley JH, Kadowitz PJ. A review of the pathophysiology and novel treatments for erectile dysfunction. Advances in Pharmaco-logical Sciences. 2010; 2010: 730861.

[4] Gupta MA, Gupta AK. Psoriasis and sex: a study of moderately to severely affected patients. International Journal of Dermatology. 1997; 36: 259–262.

[5] Meeuwis KAP, de Hullu JA, van de Nieuwenhof HP, Evers AWM, Massuger LFAG, van de Kerkhof PCM, et al. Quality of life and sexual health in patients with genital psoriasis. British Journal of Dermatology. 2011; 164: 1247–1255.

[6] Wojciechowska-Zdrojowy M, Reich A, Szepietowski JC, Woj-ciechowski A. Analysis of sexual problems in men with psoriasis. Journal of Sex & Marital Therapy. 2018; 44: 737–745.

[7] Bell KA, Balogh EA, Feldman SR. An update on the impact of depression on the treatment of psoriasis. Expert Opin Pharmacother. 2021; 22: 695–703. (in press)

[8] Russo PA, Ilchef R, Cooper AJ. Psychiatric morbidity in psoriasis: a review. Australasian Journal of Dermatology. 2004; 45: 155–159.

[9] Wu JJ, Feldman SR, Koo J, Marangell LB. Epidemiology of mental health comorbidity in psoriasis. Journal of Dermatological Treatment. 2018; 29: 487–495.

[10] Cabete J, Torres T, Vilarinho T, Ferreira A, Selores M. Erectile dysfunction in psoriasis patients. European Journal of Dermatology. 2014; 24: 482–486.

[11] Chen Y, Chen C, Lin M, Chen T, Li C, Hwang C, et al. Increased risk of sexual dysfunction in male patients with psoriasis: a nationwide population-based follow-up study. Journal of Sexual Medicine. 2013; 10: 1212–1218.

[12] Wylie G, Evans CD, Gupta G. Reduced libido and erectile dysfunction: rarely reported side-effects of methotrexate. Clinical and Experimental Dermatology. 2009; 34: e234.

[13] Aguirre MA, Vélez A, Romero M, Collantes E. Gynecomastia and sexual impotence associated with methotrexate treatment. The Journal of Rheumatology. 2002; 29: 1793–1794.

[14] Cemil BC, Cengiz FP, Atas H, Ozturk G, Canpolat F. Sex hormones in male psoriasis patients and their correlation with the Psoriasis Area and Severity Index. Journal of Dermatology. 2015; 42: 500–503.

[15] Özer İ, Temiz SA, Ataseven A, Dursun R, Uyar M, Özer M. Is prenatal testosterone-estrogen balance associated with psoriasis? Dermatologic Therapy. 2020; 33: e14213.

[16] Bardazzi F, Odorici G, Ferrara F, Magnano M, Balestri R, Patrizi A. Sex and the PASI: patients affected by a mild form of psoriasis are more predisposed to have a more severe form of erectile dysfunction. Journal of the European Academy of Dermatology and Venereology. 2016; 30: 1342–1348.

[17] Ji S, Zang Z, Ma H, Gu M, Han Y, Wang L, et al. Erectile dysfunction in patients with plaque psoriasis: the relation of depression and cardiovascular factors. International Journal of Impotence Research. 2016; 28: 96–100.

[18] Ardahanlı İ, Celik M. Can myocardial performance index predict early cardiac risks in erectile dysfunction? Aging Male. 2020; 1–7.

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