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Open Access Special Issue

A comprehensive mechanistic basis of prostate cancer advancement & its personalized implementation-bridging the gap: present state and future prospect

  • Dipamoy Datta1
  • Md Aftabuddin2
  • Raja Kundu3
  • Mayank Baid4,5
  • Sanjoy Kumar Das6
  • Supriti Sarkar7
  • Suresh Bajoria8
  • Tapan Kumar Mandal9
  • Pragnadyuti Mandal10
  • Chandan Banerjee11
  • B Shiva Shankar5,12
  • Anish Banerjee13
  • Chinmay Kumar Panda14
  • Sougata Sarkar15
  • Nilkantha Garain16
  • Subrata Chakraborty17
  • Anirban Sinha18
  • Chaitali Banerjee19
  • Losiana Nayak20
  • Aniruddha Bagchi21
  • Subhadra Roy22
  • Kaushik Goswami23
  • Leena Kumari24

1Department of Biotechnology, Siksha Bhavana, Visva-Bharati, 731235 Santiniketan, India

2Department of Information Scientist, Maulana Abul Kalam Azad University of Technology, Haringhata, 741249 Simhat, India

3Computer Education Training Program, NICS Computer, 700032 Kolkata, India

4Department of Urology, S.V.S Marwari Hospital, 700014 Kolkata, India

5Department of Urology, AMRI Hospitals-Salt Lake, Salt Lake City, 700098 Kolkata, India

6Department of Oncology, S.V.S Marwari Hospital, 700014 Kolkata, India

7Department of Zoology, City College, 700009 Kolkata, India

8Department of Urology & Oncology, Rabindranath Tagore International Institute of Cardiac Sciences, 700099 Kolkata, India

9Department of Urology, Nil Ratan Sircar Medical College & Hospital, 700014 Kolkata, India

10Department of Pharmacology, Medical College, 700073 Kolkata, India

11Department of Radiotherapy, IPGMER and SSKM Hospital, 700020 Kolkata, India

12Department of Urology, North City Hospital, 700054 Kolkata, India

13Department of Radiotherapy, Medical College, 700073 Kolkata, India

14Department of Oncogene Regulation, Chittaranjan National Cancer Institute, 700026 Kolkata, India

15Department of Clinical & Experimental Pharmacology, Calcutta School of Tropical Medicine, 700073 Kolkata, India

16Department of Information Technology, Jadavpur University, 700098 Kolkata, India

17Department of Pathology, Saroj Gupta Cancer Centre & Research Institute, 700063 Kolkata, India

18Department of Endocrinology, Medical College, 700073 Kolkata, India

19Department of Zoology, Vidyasagar College for Women, 700006 Kolkata, India

20Machine Intelligence Unit, Indian Statistical Institute, 700108 Kolkata, India

21Department of Pharmacology, IPGMER and SSKM Hospital, 700020 Kolkata, India

22Department of Zoology, Surendranath College, 700009 Kolkata, India

23Department of Computer Science, St. Xavier's College, 700016 Kolkata, India

24Department of Pharmaceutical Technology, Jadavpur University, 700032 Kolkata, India

DOI: 10.31083/jomh.2021.029 Vol.17,Issue 3,July 2021 pp.18-35

Submitted: 07 January 2021 Accepted: 06 February 2021

Published: 08 July 2021

*Corresponding Author(s): Dipamoy Datta E-mail: ddbmbg@gmail.com

PDF (181.62 kB) Supplementary material

Abstract

Despite significant achievements in prostate cancer mechanistic understanding and its targeted therapies, currently there exists several major challenges that mainly arises during the therapy of advanced prostate cancer. Present prostate cancer precision medicine strategy principally suffers from several practical concerns, particularly in point of therapeutic resistance, tumor heterogeneity, complex clinical & pathological behavior and an extensive genomic perturbation landscape.

Prostate Cancer Systems-Medicine Initiative is a global trans-disciplinary movement taken from corre-sponding scientific domains to critically determine the nature of this major existing challenges and its corresponding most possible solutions by systematically accumulating the present existing knowledge. Basically, it explains the importance of broad spectrum cancer hallmark based integrative approaches for development of combination therapy associated strategic measures for metastatic castration resistant prostate cancer. The major findings of this initiative can be summarized by identification of 136 therapeutic resistance mediators, 103 prostate cancer driver oncogenes and 8 progression pathways along with 5 terrain factors which centrally drives the basic events in prostate cancer pathogenesis, its further metastatic propagation and ultimate therapeutic resistance. In addition, it also attempts to summarize the critical features and basic challenging aspects of current therapeutic options.

Keywords

Precision medicine; Therapy resistance; Cancer hallmarks; Terrain factors; Castration resistant prostate cancer (CRPC); Bone metastasis; Androgen receptor (AR)

Cite and Share

Dipamoy Datta,Md Aftabuddin,Raja Kundu,Mayank Baid,Sanjoy Kumar Das,Supriti Sarkar,Suresh Bajoria,Tapan Kumar Mandal,Pragnadyuti Mandal,Chandan Banerjee,B Shiva Shankar,Anish Banerjee,Chinmay Kumar Panda,Sougata Sarkar,Nilkantha Garain,Subrata Chakraborty,Anirban Sinha,Chaitali Banerjee,Losiana Nayak,Aniruddha Bagchi,Subhadra Roy,Kaushik Goswami,Leena Kumari. A comprehensive mechanistic basis of prostate cancer advancement & its personalized implementation-bridging the gap: present state and future prospect. Journal of Men's Health. 2021. 17(3);18-35.

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