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Systematic review

Open Access

The efficacy and safety of thulium laser resection of bladder tumor versus standard transurethral resection in patients with non-muscle-invasive bladder cancer: a systematic review and meta-analysis

  • Yu-Meng Chai1,†
  • Yuan-Shan Cui1,2,†
  • Xiao-Yi Zhang3
  • Huan-Tao Zong1
  • Zhong-Bao Zhou1
  • Yong Zhang1

1Department of Urology, Beijing Tiantan Hospital, Capital Medical University, 100070 Beijing, P. R. China

2Department of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, 266101 Shandong, P. R. China

3Department of Urology, PLA Rocket Force Characteristic Medical Center, 100088 Beijing, P. R. China

DOI: 10.31083/jomh.2021.023 Vol.17,Issue 2,April 2021 pp.32-42

Published: 08 April 2021

*Corresponding Author(s): Yong Zhang E-mail:

† These authors contributed equally.

PDF (4.42 MB)


Purpose: This study was to analyze the efficacy and safety of thulium laser resection of bladder tumor (Tm-TURBT) versus TURBT for patients with non-muscle-invasive bladder cancer (NMIBC).

Materials and Methods: Randomized controlled trial data were retrieved using the MEDLINE, Embase, Web of Science, and the Cochrane Library. We also searched Chinese databases including Chinese National Knowledge Infrastructure (CNKI), Wanfang data and VIP data.

Results: A total of sixteen articles including 1662 participants were enrolled into our meta-analysis. We found no significant difference in terms of operation time, urethral stricture, 1-year recurrence rate, overall 1-year recurrence rate and overall 3-year recurrence rate between the two groups. Less intraoperative blood loss and a lower incidence of obturator nerve reflex (ONR), bladder perforation and bladder irritation were identified in Tm-TURBT group than in TURBT group in our analysis. The analysis also demonstrated faster postoperative recovery in terms of the catheterization, bladder irrigation and hospitalization time in Tm-TURBT group. The subgroup analysis was conducted based on different postoperative chemotherapy (epirubicin and non-epirubicin) concerning recurrence rate whereas no significant difference was noted.

Conclusion: Tm-TURBT is an efficient and safe treatment for NMIBC and it could be an alternative choice for TURBT. Given that some limitations are clearly identified, more large-scale and well-designed RCTs are needed to confirm our findings.


Transurethral resection of bladder tumor; Bladder tumor; Thulium laser; Meta-analysis; Randomized controlled trials

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Yu-Meng Chai,Yuan-Shan Cui,Xiao-Yi Zhang,Huan-Tao Zong,Zhong-Bao Zhou,Yong Zhang. The efficacy and safety of thulium laser resection of bladder tumor versus standard transurethral resection in patients with non-muscle-invasive bladder cancer: a systematic review and meta-analysis. Journal of Men's Health. 2021. 17(2);32-42.


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