ASSOCIATION OF THE SERUM IGG LEVEL AGAINST PERIODONTAL BACTERIA WITH PERIODONTAL STATUS AND SERUM LIPID LEVELS
1Department of Oral Health, Nagasaki University Graduate School of Biomedical Sciences
2Community Medical Network Center, Nagasaki University Hospital
3Department of Community Oral Health, School of Dentistry, Asahi University
4Department of Island and Community Medicine, Nagasaki University Graduate School of Biomedical Sciences
DOI: 10.22374/1875-68184.108.40.206 Vol.14,Issue 4,September 2018 pp.11-17
Published: 24 September 2018
Background and Objective
Several studies have reported that serum antibodies against periodontal pathogens are related not only to periodontal status but also to systemic conditions, such as glycemic control and serum lipids. Therefore, this study examined the associations of serum IgG antibodies against periodontal pathogens with periodontal status and serum lipid levels in community dwellers.
Materials and Methods
A community-based cross-sectional study of 409 subjects (140 men, 269 women) aged ≥ 40 years who had at least 5 teeth was conducted in Goto, Japan in 2009 and 2010.
The serum IgG levels against Porphyromonas gingivalis were significantly associated with periodontal parameters and serum high-density lipoprotein cholesterol (HDL-C) in men. According to a multiple linear regression analysis adjusted for covariates, the serum IgG levels against P. gingivalis were inversely related to serum HDL-C (B = −0.1; P = 0.004).
This study suggests that an elevated immune response to the periodontal pathogen is independently cor-related with lower serum HDL-C level in community-dwelling men.
Periodontitis; Periodontal bacteria; Serum IgG antibody, HDL-cholesterol
Reiko Furugen,Hideaki Hayashida,Koji Kawasaki,Masayasu Kitamura,Takahiro Iwasaki,Toshiyuki Saito,Takahiro Maeda. ASSOCIATION OF THE SERUM IGG LEVEL AGAINST PERIODONTAL BACTERIA WITH PERIODONTAL STATUS AND SERUM LIPID LEVELS. Journal of Men's Health. 2018. 14(4);11-17.
1. Haffajee AD, Socransky SS. Microbiology of peri-odontal diseases: introduction. Periodontology 2000 2005;38:9–12.
2. Murayama Y, Nagai A, Okamura K, et al. Serum im-munoglobulin G antibody to periodontal bacteria. Adv Dent Res 1988;2(2):339–45.
3. Kudo C, Naruishi K, Maeda H, et al. Assessment of the plasma/serum IgG test to screen for periodontitis. J Dent Res 2012;91(12):1190–5.
4. Sugi N, Naruishi K, Kudo C, et al. Prognosis of peri-odontitis recurrence after intensive periodontal treatment using examination of serum IgG antibody titer against periodontal bacteria. J Clin Lab Anal 2011;25(1):25–32.
5. Saito T, Shimazaki Y, Sakamoto M. Obesity and peri-odontitis. N Engl J Med 1998;339(7):482–3.
6. Loe H. Periodontal disease. The sixth complication of diabetes mellitus. Diabet Care 1993;16(1):329–34.
7. Katz J, Flugelman MY, Goldberg A, et al. Association between periodontal pockets and elevated cholesterol and low density lipoprotein cholesterol levels. J Peri-odontol 2002;73(5):494–500.
8. Losche W, Karapetow F, Pohl A, et al. Plasma lipid and blood glucose levels in patients with destructive peri-odontal disease. J Clin Periodontol 2000;27(8):537–41.
9. Moore KJ, Tabas I. Macrophages in the pathogenesis of atherosclerosis. Cell 2011;145(3):341–55.
10. Gibson FC, 3rd, Hong C, Chou HH, et al. Innate immune recognition of invasive bacteria accelerates atherosclerosis in apolipoprotein E-deficient mice. Circulation 2004;109(22):2801–6.
11. Zaremba M, Gorska R, Suwalski P, et al. Evaluation of the incidence of periodontitis-associated bacteria in the atherosclerotic plaque of coronary blood vessels. J Periodontol 2007;78(2):322–7.
12. MacAulay MA, Jacklyn CL, Mathers JM, et al. Con-tinuous-flow enzymatic determination of total serum cholesterol and method standardization with CDC-calibrated pooled sera. Clin Chem 1980;26(7):896–902.
13. Sullivan DR, Kruijswijk Z, West CE, et al. Determina-tion of serum triglycerides by an accurate enzymatic method not affected by free glycerol. Clin Chem 1985;31(7):1227–8.
14. Okada M, Matsui H, Ito Y, et al. Direct measurement of HDL cholesterol: method eliminating apolipoprotein
E- rich particles. J Clin Lab Anal 2001;15(4):223–9.
15. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18(6):499–502.
16. Fritsche HA, Dee JW, Adams-Park HR. Enzymatic end-point analysis of glucose with the hexokinase method and the Union Carbide fast centrifugal analyzer. Clin Biochem 1975;8(4):240–6.
17. Kopp HP, Festa A, Hopmeier P, et al. [Evaluation of a new method for determining glycated hemoglobin with monoclonal antibodies (DCA 2000)]. Wiener klinische Wochenschrift 1996;108(1):16–9.
18. Brown LJ, Brunelle JA, Kingman A. Periodontal status in the United States, 1988-1991: prevalence, extent, and demographic variation. J Dent Res 1996;75 Spec No:672–83.
19. Hayashida H, Saito T, Kawasaki K, et al. Association of periodontitis with carotid artery intima-media thickness and arterial stiffness in community-dwelling people in Japan: the Nagasaki Islands study. Atherosclerosis 2013;229(1):186–91.
20. Cekici A, Kantarci A, Hasturk H, et al. Inflammatory and immune pathways in the pathogenesis of periodontal disease. Periodontol 2000 2014;64(1):57–80.
21. Nakagawa S, Machida Y, Nakagawa T, et al. Infection by Porphyromonas gingivalis and Actinobacillus actino-mycetemcomitans, and antibody responses at different ages in humans. J Periodont Res 1994;29(1):9–16.
22. Gordon DJ, Probstfield JL, Garrison RJ, et al. High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies. Circulation 1989;79(1):8–15.
23. Khovidhunkit W, Kim MS, Memon RA, et al. Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host. J Lipid Res 2004;45(7):1169–96.
24. Post WS, Budoff M, Kingsley L, et al. Associations between HIV infection and subclinical coronary ath-erosclerosis. Ann Intern Med 2014;160(7):458–67.
25. Feingold KR, Grunfeld C. The acute phase response inhibits reverse cholesterol transport. J Lipid Res 2010;51(4):682–4.
26. Fisher EA, Feig JE, Hewing B, et al. High-density lipoprotein function, dysfunction, and reverse cho-lesterol transport. Arterioscler Thromb Vasc Biol 2012;32(12):2813–20.
27. Nizam N, Gumus P, Pitkanen J, et al. Serum and salivary matrix metalloproteinases, neutrophil elastase, myeloperoxidase in patients with chronic or aggressive periodontitis. Inflammation 2014;37(5):1771–8.
28. Wakatsuki A, Ikenoue N, Sagara Y. Effects of estrogen on susceptibility to oxidation of low-density and high-density lipoprotein in postmenopausal women. Maturitas 1998;28(3):229–34.
Science Citation Index Expanded Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,200 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.
Social Sciences Citation Index Social Sciences Citation Index contains over 3,400 journals across 58 social sciences disciplines, as well as selected items from 3,500 of the world’s leading scientific and technical journals. More than 9.37 million records and 122 million cited references date back from 1900 to present.
Current Contents - Social & Behavioral Sciences Current Contents - Social & Behavioral Sciences provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in the social and behavioral sciences.
Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.
SCOPUS Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.
DOAJ DOAJ is a community-curated online directory that indexes and provides access to high quality, open access, peer-reviewed journals.
CrossRef Crossref makes research outputs easy to find, cite, link, assess, and reuse. Crossref committed to open scholarly infrastructure and collaboration, this is now announcing a very deliberate path.
Portico Portico is a community-supported preservation archive that safeguards access to e-journals, e-books, and digital collections. Our unique, trusted process ensures that the content we preserve will remain accessible and usable for researchers, scholars, and students in the future.