Effects of Resistance Exercise Intensity on Cytokine and Chemokine Gene Expression in Atopic Dermatitis Mouse Model
1Assistant Professor, Department of Physical Education, Daegu Catholic University, Gyeongsan, Korea
2Associate Professor, Sports and Health Care Major, College of Humanities and Arts, Korea National University of Transportation, Chungju-si, Korea
DOI: 10.22374/1875-68220.127.116.11 Vol.14,Issue 2,February 2018 pp.14-21
Published: 22 February 2018
Background and Objective
Although the evidence is unclear, literature indicates that resistance exercise reduces inflammation in colorectal disease. The purpose of this study was to identify the effects of colon tissue on cytokine and chemokine gene expression with changes in resistance exercise intensity.
Material and Methods
We divided male BABL/c mice into 6 groups (each group n=10, total=60) (control group: CON, low re-sistance exercise group: EX_L, high resistance exercise group: EX_H, atopic dermatitis group: AD, atopic dermatitis+low resistance exercise group: AD+EX_L, atopic dermatitis+high resistance exercise group: AD+EX_H) and subjected them to ladder climbing resistance exercise for 4 weeks. After 24 h of each exercise schedule, a real-time polymerase chain reaction was performed to determine mRNA expression of interleukin-6 (IL-6) and chemokine ligand 20 (CCL20).
The AD group showed significantly higher mRNA expression of IL-6 and CCL20 compared with the CON, EX_L, EX_H, AD+EX_L, and AD+EX_H groups (p<0.05).
In conclusion, both high and low resistance exercise effectively decreases the concentration of IL-6 and CCL20 in mice with and without AD.
Eun-Ju Choi,Wi-Young So. Effects of Resistance Exercise Intensity on Cytokine and Chemokine Gene Expression in Atopic Dermatitis Mouse Model. Journal of Men's Health. 2018. 14(2);14-21.
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