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Special Issue Title:

Reproductive function abnormalities in males with obesity, metabolic syndrome and type 2 diabetes: a two-way street

Deadline for manuscript submissions: 30 March 2022

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Special Issue Editor

  • Guest Editor

    Angelo Di VincenzoE-MailWebsite

    Internal Medicine Unit, Camposampiero Hospital, Italy; Department of Medicine, University-Hospital of Padova, Italy

    Interests: Metabolic Syndrome; Cardiovascular Risk; Metabolism; Inflammatory Biomarkers; Metabolic Endocrinology

Special Issue Information

Dear Colleagues,

The epidemic of obesity and metabolic syndrome has resulted in a stressful impact on health systems worldwide. There is currently considerable effort in both the clinical and research settings to reduce the burden of associated health complications such as coronary heart disease, heart failure and stroke. However, these are also associated with other conditions that are often not recognized and/or undertreated, such as reproductive function abnormalities. In males, these complications severely affect quality of life, but their diagnosis and treatment are often inadequate. 

Obesity and type 2 diabetes promote an array of abnormalities, with erectile dysfunction, hypogonadism and infertility being amongst the most common. Furthermore, high BMI is associated with urological manifestations, with weight gain putting patients at a higher risk of developing lower urinary tract symptoms. Prostate activity also seems to be impaired in obese patients, with some showing abnormal semen quality and retrograde ejaculation. 

Interestingly, there is growing evidence to suggest the relationship between reproductive and metabolic abnormalities is bidirectional, with impaired hormonal synthesis/activity independently promoting the development of metabolic syndrome and type 2 diabetes. This was suggested from studies reporting that patients undergoing androgen deprivation therapy for metastatic prostate cancer were at high risk of developing type 2 diabetes. Other studies showed an amelioration of the associated metabolic abnormalities in hypogonadal patients treated with testosterone replacement therapy. Furthermore, newly developed therapies for metabolic disturbances have also shown some potential for improving reproductive health. 

In light of the above findings, this research area deserves further investigation in order to provide novel strategies for improving men’s health and quality of life. This Special Issue presents recent research aimed at clarifying the interconnection between reproductive function abnormalities and obesity, metabolic syndrome and type 2 diabetes in men. Hence, the topic of submitted papers may not be limited to the reported keywords listed below. 

Guest Editor,

Angelo Di Vincenzo


Obesity; Type 2 diabetes; Male reproductive abnormalities; Testosterone; Androgen; Sexual function; Erectile dysfunction; Male obesity-secondary hypogonadism; LUTS

Manuscript Submission Information

Submissions will be accepted on a rolling basis and reviewed by experts in the field. Rapid peer review and prompt editorial decisions will ensure that quality manuscripts are published on time. The manuscript has not already been published or submitted elsewhere (except conference proceedings papers). If similar work has been published or submitted elsewhere, you must provide a copy of the submitted manuscript. You may not submit your manuscript elsewhere while it is under consideration at the Journal of Men's Health. All manuscripts undergo thorough double-blind peer-review. To check the suitability of the special issue for publishing your manuscript, please read the journal's aims and scope and read or download the guide for authors. You may also send a brief abstract of your work (about 100 words) to the Editorial Office at A guide for authors and other relevant information for manuscript submission is available on the Instructions for Authors page.

Academic Writing and English Language Editing Services

Authors who feel that their manuscript may benefit from additional academic writing or language editing support before submission are strongly encouraged to use academic editing services.

Article Processing Charges (APC)

All manuscripts submitted to the Journal of Men's Health are assessed according to the journal standard editorial criteria. If accepted for publication, an Article Processing Charge of 1250 USD applies.

Type of Articles: Original Research, Review, Mini-Review, Systematic Review, Short Communication, Case Report, Letter to the Editor, Commentary, Rapid Report, Meeting Report, News and Views

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