Main Article Content
Reproductive protection; fertility impairment; malignant tumor; sperm cryopreservation
The aim of this study was to assess the awareness of fertility protection among male patients and their healthcare providers in the treatment process of cancer.
In a cross-sectional study, we applied a questionnaire survey among patients and healthcare providers who were selected randomly: the physician group consisted of oncologists and hematologists, and the patient group included participants with cancer from 15 to 45 years old, who were recruited from hos-pitals in Qingdao. Meanwhile, data from male cancer patients, who received sperm cryopreservation in our hospital, were also analyzed.
Data collected from healthcare provider group showed that more than 80% of clinicians warned patients of the fertility impairment along with chemotherapy or other treatments, whereas a few clinicians recommended specific methods for reproductive protection to patients with special attention be paid to the follow-up fertility result. In patient group, more than 50% indicated they would accept the loss of fertility caused by cancer therapies. The rate of awareness of sperm cryopreservation, as an effective way of reproductive protection, was low among both physician and patient groups. In the past 3 years, only 63 samples of semen from 54 cancer patients were cryopreserved in our hospital.
2. Karunakaran P, Malhotra P, Lad D. Fertility management for the hemato-oncologist. Indian J Hematol Blood Transfus 2018; 34(1):13–18. https://doi.org/10.1007/s122 88-01 7-08 87-8
3. Bunge RG, Sherman JK. Fertilizing capacity of frozen human spermatozoa. Nature 1953; 172(4382): 767–8. https://doi.org/10.1038/ 17276 7b0
4. Kawai K, Nishiyama H. Preservation of fertility of adult male cancer patients treated with chemotherapy. Int J Clin Oncol. 2019;24:34–40. https:// doi.org/10.1007/s10147-018-1333-0
5. Yogev L, Kleiman SE, Shabtai E, et al. Long-term cryostorage of sperm in a human sperm bank does not damage progressive motility concentration. Hum Reprod 2010;25(5):1097–103. https://doi. org/10.1093/humrep/deq041
6. Okada K, Fujisawa M. Recovery of spermatogenesis following cancer treatment with cytotoxic chemotherapy and radiotherapy. World J Mens Health. 2019;37(2):166–174 https://doi.org/ 10.5534/wjmh.180043
7. Mancini J, Rey D, Préau M, et al. Infertility induced by cancer treatment: Inappropriate or no information provided to majority of French survivors of cancer. Fertil Steril 2008;90(5):1616– 25. https://doi.org/10.1016/j.fertnstert.2007.08. 064
8. Moody JA, Ahmed K, Yap T, Minhas S, Shabbir M. Fertility management in testicular cancer: The need to establish a standardized and evidence-based patient-centric pathway. BJU Int 2019;123:160–72. https://doi.org/10.1111/bju.14455
9. Stern C, Agresta F. Setting up a fertility preservation programme. Best Pract Res Clin Obstet Gynaecol 2019;55:67–78. https://doi.org/10.1016/ j.bpobgyn.2018.07.007
10. Horne G, Atkinson AD, Pease EH, et al. Live birth with sperm cryopreserved for 21 years prior to cancer treatment: Case report. Hum Reprod 2004;19(6):1448–9. https://doi.org/10.1093/hum-rep/deh249
11. Feldschuh J, Brassel J, Durso N, et al. Successful sperm storage for 28 years. Fertil Steril 2005;84(4):1017. https://doi.org/10.1016/j.fertn-stert.2005.05.015
12. Liu F, Zou SS, Zhu Y, et al. A novel micro-straw for cryopreservation of small number of human spermatozoon. Asian J Androl 2016. https://doi. org/10.4103/1008-682X.173452
13. Rabah DM, Wahdan IH, Merdawy A, et al. Oncologists’ knowledge and practice towards sperm cryopreservation in Arabic communities. J Cancer Survive 2010;4(3):279–83. https://doi. org/10.1007/s11764-010-0140-z
14. Shnorhavorian M, Harlan LC, Smith AW, et al. Fertility preservation knowledge, counseling, and actions among adolescent and young adult patients with cancer: A population-based study. Cancer 2015;121(19):3499–506. https://doi. org/10.1002/cncr.29328
15. Daudin M, Rives N, Walschaerts M, et al. Sperm cryopreservation in adolescents and young adults with cancer: Results of the French national sperm banking network (CECOS). Fertil Steril 2015,103(2):478–86. https://doi.org/10.1016/j. fertnstert.2014.11.012
16. Besharati M, Woodruff T, Victorson D. Young adults’ access to fertility preservation services at National Cancer Institute Community Oncology Research Program minority/underserved community sites: A qualitative study. J Adolesc Young Adult Oncol 2016;5(2):187–200. https://doi. org/10.1089/jayao.2015.0034
17. 盛慧强, 张欣宗, 洪艳。男性肿瘤患者精液冷冻 保存后常规参数分析. 中华男科学杂志 2015;21(1): 44–7.
18. Chung JP, Haines CJ, Kong GW. Sperm cryopreservation for Chinese male cancer patients: A 17-year retrospective analysis in an assisted reproductive unit in Hong Kong. Hong Kong Med J 2013;19(6): 525–30. https://doi.org/10.12809/hkmj134055
19. Ping P, Gu BH, Li P, et al. Fertility outcome of patients with testicular tumor: Before and after treatment. Asian J Androl 2014;16(1):107–11. https://doi.org/10.4103/1008-682X.122194
20. Traila A, Dima D, Achimas-Cadariu P, Micu R. Fertility preservation in Hodgkin’s lymphoma patients that undergo targeted molecular therapies: An important step forward from the chemotherapy era. Cancer Manage Res 2018;10:1517–26. https:// doi.org/10.2147/CMAR.S154819