Journal of Men's Health <p>The Journal of Men’s Health (JOMH) is a peer-reviewed publication covering all aspects of men’s health across the lifespan. As the official journal the International Society of Men’s Health (ISMH) the Journal publishes cutting-edge advances in a wide range of diseases and conditions, including diagnostic procedures, therapeutic management strategies, and innovative clinical research in gender-based biology to ensure optimal patient care. The Journal addresses disparities in health and life expectancy between men and women; increased risk factors such as smoking, alcohol abuse, and obesity; higher prevalence of diseases such as heart disease and cancer; and health care in underserved and minority populations.</p> The Dougmar Publishing Group en-US Journal of Men's Health 1875-6859 Vitamin D and Semen Quality in Urban, Young, Healthy Men (AndroLS) <p><strong>Background and Objective:</strong> Our aim was to evaluate whether the blood concentration of 25(OH)D<sub>3</sub> is associated with semen quality and sperm morphology parameters in young men.</p> <p><strong>Material and methods:</strong> Healthy, urban volunteers aged 20-35 were recruited from universities, clubs and societies in the macroregion of Lower Silesia (Poland). We evaluated medical history, lifestyle factors and environmental threats, collected semen samples, and evaluated vitamin D levels. We acquired data for 177 subjects.</p> <p><strong>Results:</strong> The mean concentration of 25(OH)D<sub>3</sub>was 13.7 ± 8.9 ng/ml. Only a minority of the included subjects (18%) had a serum 25(OH)D<sub>3 </sub>concentration above the lower limit (20 ng/ml). In total, 39% had severe vitamin D deficiency (&lt;10 ng/ml). None of the studied semen parameters was correlated with the serum concentration of 25(OH)D<sub>3</sub>; we also found no correlations after adjusting for alcohol consumption, cigarette smoking, carrying a mobile phone in pant pockets, body mass index, caffeine consumption and physical activity.</p> <p><strong>Conclusion:</strong> Our data indicate that the serum concentration of 25(OH)D<sub>3 </sub>was not correlated with semen quality in a healthy, young urban population with prevalent vitamin D insufficiency.</p> Pawel Jozkow, MD, PhD Małgorzata Słowińska-Lisowska, MSc, PhD Aleksandra Zagrodna, MSc, PhD Marek Mędraś, MD, PhD Felicja Lwow, MSc, PhD Copyright (c) 2018 Journal of Men's Health 2018-02-22 2018-02-22 14 2 e1 e7 10.22374/1875-6859.14.2.1 Effects of Exercise Intensity on Alcohol Dehydrogenase Gene Expression in the Rat Large Intestine <p><strong>Background and Objective</strong>: The aim of this study was to examine the relationship between the intensity of treadmill exercise and alcohol dehydrogenase (ADH) expression in the large intestine.</p> <p><strong>Material and Methods:</strong> Thirty Sprague-Dawley white male rats were randomly assigned to a control group (CON; no exercise), low-intensity exercise group (LIG; 30-min exercise at 8 m/min 5 times a week for 4 weeks), or high-intensity exercise group (HIG; 30-min exercise at 28 m/min 5 times a week for 4 weeks).</p> <p><strong>Results:</strong> A microarray analysis was conducted to evaluate ADH gene expression levels in large intestinal tissue, which showed significant changes in the expression of four ADH genes (<em>Adh1</em>, <em>Adh4</em>, <em>Adh6a</em>, and <em>Adh7</em>) related to exercise intensity. In addition, pooled samples of the exercise groups showed decreased expression levels of these four genes compared with those of the control group. These findings were confirmed by reverse transcription-polymerase chain reaction. In addition, differences were detected with respect to exercise intensity: <em>Adh1</em>, <em>Adh4</em>, and <em>Adh6a</em> levels were significantly decreased in the LIG compared with those in the HIG, whereas <em>Adh7</em> expression showed an opposite trend.</p> <p><strong>Conclusion:</strong> In conclusion, this study suggests that regular exercise can decrease the incidence of alcohol-related disease by suppressing ADH production in the digestive system.</p> Eun-Ju Choi Wi-Young So Copyright (c) 2018 2018-03-13 2018-03-13 14 2 e8 e13 10.22374/1875-6859.14.2.2